[PMID 18474871
] This study compared 608 patients of European ancestry with papillary thyroid cancer, which is the most common form of thyroid cancer and is highly treatable, to 901 healthy controls. The authors found an association between the SNP rs2910164, which is equivalent to the 23andMe SNP rs2961920, and risk for thyroid cancer. People with the AC genotype at rs2961920 had about 1.5 times the odds of papillary thyroid cancer compared to those with the AA genotype and about three times the odds compared to the CC genotype. Though this is an atypical risk pattern, the researchers speculate in a separate paper that having one copy of each form of the SNP increases production of molecules that regulate the cell's response to DNA damage, a process that is often involved in cancer.
] This study compared 608 patients of European ancestry with papillary thyroid cancer, which is the most common form of thyroid cancer and is highly treatable, to 901 healthy controls. The authors found an association between the SNP rs2910164, which is equivalent to the 23andMe SNP rs2961920, and risk for thyroid cancer. People with the AC genotype at rs2961920 had about 1.5 times the odds of papillary thyroid cancer compared to those with the AA genotype and about three times the odds compared to the CC genotype. Though this is an atypical risk pattern, the researchers speculate in a separate paper that having one copy of each form of the SNP increases production of molecules that regulate the cell's response to DNA damage, a process that is often involved in cancer.
