rs299290

Orientation

plus

Stabilized

plus

Make rs299290(C;C)

Make rs299290(C;T)

Make rs299290(T;T)

Reference

GRCh38 38.1/141

Chromosome

5

Position

163475510

Gene

HMMR

is a	snp
is	mentioned by
dbSNP	rs299290
dbSNP (classic)	rs299290
ClinGen	rs299290
ebi	rs299290
HLI	rs299290
Exac	rs299290
Gnomad	rs299290
Varsome	rs299290
LitVar	rs299290
Map	rs299290
PheGenI	rs299290
Biobank	rs299290
1000 genomes	rs299290
hgdp	rs299290
ensembl	rs299290
geneview	rs299290
scholar	rs299290
google	rs299290
pharmgkb	rs299290
gwascentral	rs299290
openSNP	rs299290
23andMe	rs299290
SNPshot	rs299290
SNPdbe	rs299290
MSV3d	rs299290
GWAS Ctlg	rs299290

GMAF

0.3223

Max Magnitude

0

?

(C;C) (C;T) (T;T)

28

cancergenetics The risk of breast cancer was 23% higher in women who had one copy of genetic variant (the A-C-A haplotype: rs7712023-rs299290-rs10515860), and 46% higher in women with two copies. In addition, those women were diagnosed an average of 12 months younger than women from the control group, suggesting that HMMR is linked to early-onset breast cancer.

However, a more recent, larger European case-control study found no association between rs299290 and risk of breast cancer.[PMID 19065580]

[PMID 19064580] breast cancer

rs10515860 [odds ratio (OR; AA/GG), 0.85; 95% confidence interval (CI), 0.65-1.12; P(trend) = 0.9],
rs299290 [OR (CC/TT), 1.00; 95% CI, 0.87-1.15; P(trend) = 0.7],
rs3756648 (rs7712023) [OR (TT/CC), 0.93; 95% CI, 0.84-1.02; P(trend) = 0.1],
rs299284 [OR (TT/CC), 1.01; 95% CI, 0.76-1.35; P(trend) = 0.5], and
rs13183712 [OR (TT/GG), 1.04; 95% CI, 0.88-1.23; P(trend) = 0.6].