rs3077

minus

Geno	Mag	Summary
(C;C)	2	1.8 times higher odds of having chronic hepatitis B
(T;T)	0	common in complete genomics

Make rs3077(C;T)

Reference

GRCh38 38.1/141

Chromosome

6

Position

33065245

Gene

HLA-DPA1

is a	snp
is	mentioned by
dbSNP	rs3077
dbSNP (classic)	rs3077
ClinGen	rs3077
ebi	rs3077
HLI	rs3077
Exac	rs3077
Gnomad	rs3077
Varsome	rs3077
LitVar	rs3077
Map	rs3077
PheGenI	rs3077
Biobank	rs3077
1000 genomes	rs3077
hgdp	rs3077
ensembl	rs3077
geneview	rs3077
scholar	rs3077
google	rs3077
pharmgkb	rs3077
gwascentral	rs3077
openSNP	rs3077
23andMe	rs3077
SNPshot	rs3077
SNPdbe	rs3077
MSV3d	rs3077
GWAS Ctlg	rs3077

GMAF

0.3962

Max Magnitude

2

?

(C;C) (C;T) (T;T)

28

23andMe blog rs3077(A) and rs9277535(A) may reduce risk of Hepatitis B infection

[PMID 21346778 ] Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver

[PMID 21750111] A Genome-Wide Association Study of Chronic Hepatitis B Identified Novel Risk Locus in a Japanese Population

[PMID 22363396 ] HBV-Related Hepatocellular Carcinoma Susceptibility Gene KIF1B Is Not Associated with Development of Chronic Hepatitis B

[PMID 22448225 ] A Common HLA-DPA1 Variant Is Associated with Hepatitis B Virus Infection but Fails to Distinguish Active from Inactive Caucasian Carriers

[PMID 22543033] Relationship between HLA-DP gene polymorphisms and clearance of chronic hepatitis B virus infections: Case-control study and meta-analysis

[PMID 22536334 ] A Genome-Wide Homozygosity Association Study Identifies Runs of Homozygosity Associated with Rheumatoid Arthritis in the Human Major Histocompatibility Complex

[PMID 22105689] Genetic variants in HLA-DP/DQ influence both hepatitis B virus clearance and hepatocellular carcinoma development.

[PMID 22737229 ] Genome-Wide Association Study Confirming Association of HLA-DP with Protection against Chronic Hepatitis B and Viral Clearance in Japanese and Korean

[PMID 20436909 ] The textile plot: a new linkage disequilibrium display of multiple-single nucleotide polymorphism genotype data.

[PMID 21310144] Non-invasive screening of HLA-DPA1 and HLA-DPB1 alleles for persistent hepatitis B virus infection: susceptibility for vertical transmission and toward a personalized approach for vaccination and treatment.

[PMID 21402545 ] A common HLA-DPA1 variant is a major determinant of hepatitis B virus clearance in Han Chinese.

[PMID 21408128 ] Evaluation of genetic susceptibility loci for chronic hepatitis B in Chinese: two independent case-control studies.

[PMID 23326374 ] Host genetic factors affecting spontaneous HBsAg seroclearance in chronic hepatitis B patients

GWAS snp
PMID	[PMID 23760081]
Trait	Chronic hepatitis B infection
Title	A genome-wide association study identified new variants associated with the risk of chronic hepatitis B.
Risk Allele
P-val	5E-39
Odds Ratio	1.89 [1.69-2.08]

[PMID 24465836 ] Genetic association of human leukocyte antigens with chronicity or resolution of hepatitis B infection in thai population

[PMID 23428460] Genetic variants in HLA-DP/DQ contribute to risk of cervical cancer: a two-stage study in Chinese women.

[PMID 23449268] HLA-DP and IL28B polymorphisms: influence of host genome on hepatitis B surface antigen seroclearance in chronic hepatitis B.

[PMID 23601003] Association of the rs3077 and rs9277535 polymorphisms in HLA-DP with hepatitis B virus infection and spontaneous clearance: a meta-analysis.

[PMID 24897020 ] Genetic Variants in Human Leukocyte Antigen-DP Influence Both Hepatitis C Virus Persistence and Hepatitis C Virus F Protein Generation in the Chinese Han Population

[PMID 25802187] Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B

[PMID 25449085] [Studies on the association of single nucleotide polymorphisms of HLA-DP and DQ genes with the outcome of chronic hepatitis B virus infection]

[PMID 25376093 ] Association between single-nucleotide polymorphisms and early spontaneous hepatitis B virus e antigen seroconversion in children

[PMID 26387494] A randomized clinical trial of peginterferon alpha-2b with or without entecavir in patients with HBeAg-negative chronic hepatitis B: Role of host and viral factors associated with treatment response

[PMID 26634522] Relationship between HLA-DP gene polymorphisms and the risk of hepatocellular carcinoma: a meta-analysis.

[PMID 27252704 ] Relevance of HLA-DP/DQ and ICAM-1 SNPs among Ovarian Cancer Patients.

[PMID 27394003] Association of HLA-DP/DQ and STAT4 polymorphisms with ankylosing spondylitis in Southwest China.

[PMID 28094303 ] Genetic Polymorphisms of rs3077 and rs9277535 in HLA-DP associated with Systemic lupus erythematosus in a Chinese population.

[PMID 28267888] Role of HLA-DP and HLA-DQ on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic population.

[PMID 29467950 ] Genetic polymorphisms in HLA-DP and STAT4 are associated with IgA nephropathy in a Southwest Chinese population.

[PMID 30471179] Association of HLA-DPA1 and HLA-DPB1 polymorphisms with spontaneous HBsAg seroclearance in Caucasians.