||some effects of higher bilirubin
||effects of higher bilirubin; irinotecan toxicity
rs34983651 is one of four SNPs all describing an insertion/deletion polymorphism in the promoter region of the UGT1A1 gene; the primary entry in SNPedia for this set of SNPs is at rs34815109. Futhermore, several of these SNPs now have been merged by dbSNP to rs3064744.
The other two SNPs (besides rs34815109) that also describe the same polymorphism are:
Note: DNA testing companies reporting genotypes as "II", "DI" or "DD" for this SNP may vary in how they define those terms for this SNP. In general, based on Promethease user data, it appears as if Ancestry's v2c and v2d chips interpret the normal allele as "D", whereas 23andMe v2-v4 chips interpret it as "I". These chips (v2-v4) appear to have false negatives for this SNP, and this SNP is not reported on the v5 chip.