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rs356220

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C)
(T;T) 1.5 increased risk of Parkinson's Disease
Make rs356220(C;T)
ReferenceGRCh38 38.1/141
Chromosome4
Position89720189
GeneLOC105377329
is asnp
is mentioned by
dbSNPrs356220
dbSNP (classic)rs356220
ClinGenrs356220
ebirs356220
HLIrs356220
Exacrs356220
Gnomadrs356220
Varsomers356220
LitVarrs356220
Maprs356220
PheGenIrs356220
Biobankrs356220
1000 genomesrs356220
hgdprs356220
ensemblrs356220
geneviewrs356220
scholarrs356220
googlers356220
pharmgkbrs356220
gwascentralrs356220
openSNPrs356220
23andMers356220
SNPshotrs356220
SNPdbers356220
MSV3drs356220
GWAS Ctlgrs356220
GMAF0.4219
Max Magnitude1.5
? (C;C) (C;T) (T;T) 28


GWAS snp
PMID [PMID 20711177OA-icon.png]
Trait
Title Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease
Risk Allele T
P-val 3E-11
Odds Ratio 1.38 [1.25-1.52]
GWAS snp
PMID [PMID 21084426]
Trait
Title Genome-wide association study confirms BST1 and suggests a locus on 12q24 as risk loci for Parkinson's disease in the European population
Risk Allele T
P-val 3E-8
Odds Ratio 1.3700 [NR]
GWAS snp
PMID [PMID 21044948OA-icon.png]
Trait
Title Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21
Risk Allele A
P-val 9E-16
Odds Ratio 1.2700 [1.17-1.37]
GWAS snp
PMID [PMID 21738487OA-icon.png]
Trait
Title Web-based genome-wide association study identifies two novel Loci and a substantial genetic component for Parkinson's disease.
Risk Allele T
P-val 2E-19
Odds Ratio 1.2900 [1.22-1.36]
GWAS snp
PMID [PMID 22451204OA-icon.png]
Trait
Title Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2.
Risk Allele
P-val 8E-35
Odds Ratio 1.3800 None


[PMID 22839974OA-icon.png] UCHL1 S18Y variant is a risk factor for Parkinson's disease in Japan


[PMID 15637659OA-icon.png] Linkage disequilibrium patterns and tagSNP transferability among European populations.


[PMID 19771175OA-icon.png] Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy.


[PMID 20070850OA-icon.png] Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.


[PMID 22425546] SNCA polymorphisms, smoking, and sporadic Parkinson's disease in Japanese.

GWAS snp
PMID [PMID 24511991OA-icon.png]
Trait Parkinson's disease
Title Identification of a novel Parkinson's disease locus via stratified genome-wide association study.
Risk Allele T
P-val 1E-9
Odds Ratio 1.37 [1.23-1.51]


[PMID 30410434OA-icon.png] A Comprehensive Analysis of the Association Between SNCA Polymorphisms and the Risk of Parkinson's Disease.


[PMID 31863812] Association between SNCA rs356220 polymorphism and Parkinson's disease: a meta-analysis.