rs3738414
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 1.6 | 0.4x decreased risk of breast cancer |
| (A;G) | normal | |
| (G;G) | 0 | normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 1 |
| Position | 117210906 |
| Gene | VTCN1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs3738414 |
| dbSNP (classic) | rs3738414 |
| ClinGen | rs3738414 |
| ebi | rs3738414 |
| HLI | rs3738414 |
| Exac | rs3738414 |
| Gnomad | rs3738414 |
| Varsome | rs3738414 |
| LitVar | rs3738414 |
| Map | rs3738414 |
| PheGenI | rs3738414 |
| Biobank | rs3738414 |
| 1000 genomes | rs3738414 |
| hgdp | rs3738414 |
| ensembl | rs3738414 |
| geneview | rs3738414 |
| scholar | rs3738414 |
| rs3738414 | |
| pharmgkb | rs3738414 |
| gwascentral | rs3738414 |
| openSNP | rs3738414 |
| 23andMe | rs3738414 |
| SNPshot | rs3738414 |
| SNPdbe | rs3738414 |
| MSV3d | rs3738414 |
| GWAS Ctlg | rs3738414 |
| GMAF | 0.0854 |
| Max Magnitude | 1.6 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs3738414 is a SNP in the V-set domain containing T cell activation inhibitor 1 VTCN1 gene, which is also known as B7-H4.
A study of 500 Chinese Han women with breast cancer (and an equal number of matched controls) concluded that the rs3738414(A;A) genotype showed a significantly decreased risk of breast cancer (odds ratio 0.412, CI: 0.203-0.835).[PMID 19903360
]
[PMID 24125968] An investigation of the effects of FGFR2 and B7-H4 polymorphisms in breast cancer
