rs3740878
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 1.2 | 1.46x type II diabetes risk; common |
| (A;G) | 1.1 | 1.26x type II diabetes risk |
| Make rs3740878(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 11 |
| Position | 44236252 |
| Gene | EXT2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs3740878 |
| dbSNP (classic) | rs3740878 |
| ClinGen | rs3740878 |
| ebi | rs3740878 |
| HLI | rs3740878 |
| Exac | rs3740878 |
| Gnomad | rs3740878 |
| Varsome | rs3740878 |
| LitVar | rs3740878 |
| Map | rs3740878 |
| PheGenI | rs3740878 |
| Biobank | rs3740878 |
| 1000 genomes | rs3740878 |
| hgdp | rs3740878 |
| ensembl | rs3740878 |
| geneview | rs3740878 |
| scholar | rs3740878 |
| rs3740878 | |
| pharmgkb | rs3740878 |
| gwascentral | rs3740878 |
| openSNP | rs3740878 |
| 23andMe | rs3740878 |
| SNPshot | rs3740878 |
| SNPdbe | rs3740878 |
| MSV3d | rs3740878 |
| GWAS Ctlg | rs3740878 |
| GMAF | 0.2874 |
| Max Magnitude | 1.2 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs3740878 increases susceptibility to Type II Diabetes 1.26 times for heterozygotes (AG) and 1.46 times for homozygotes (AA) [PMID 17293876]
[PMID 17786204
] Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function.
[PMID 18443202] Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies.
[PMID 18461161] Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value.
[PMID 18544707] Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program.
[PMID 18556337] Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).
[PMID 18633108] Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.
[PMID 18689899] Exchangeable models of complex inherited diseases.
[PMID 19008344] Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians.
[PMID 19401414] Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
[PMID 21278902] Genetic risk profiling for prediction of type 2 diabetes.
[PMID 22377712] Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography.
[PMID 23052945] Association between variants of EXT2 and type 2 diabetes: a replication and meta-analysis
[PMID 25207843] Impact of variants of the EXT2 gene on Type 2 diabetes and its related traits in the Chinese han population
| ClinVar | |
|---|---|
| Risk | rs3740878(G;G) |
| Alt | rs3740878(G;G) |
| Reference | Rs3740878(A;A) |
| Significance | Non-pathogenic |
| Disease | not specified |
| Variation | info |
| Gene | EXT2 |
| CLNDBN | not specified |
| Reversed | 1 |
| HGVS | NC_000011.9:g.44257802T>C |
| CLNSRC | |
| CLNACC | RCV000251858.1, |
