rs3755351
From SNPedia
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | >1.3x risk for hypertension | |
| (A;C) | 1.3x risk for hypertension | |
| (C;C) | normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 2 |
| Position | 70747758 |
| Gene | ADD2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs3755351 |
| dbSNP (classic) | rs3755351 |
| ClinGen | rs3755351 |
| ebi | rs3755351 |
| HLI | rs3755351 |
| Exac | rs3755351 |
| Gnomad | rs3755351 |
| Varsome | rs3755351 |
| LitVar | rs3755351 |
| Map | rs3755351 |
| PheGenI | rs3755351 |
| Biobank | rs3755351 |
| 1000 genomes | rs3755351 |
| hgdp | rs3755351 |
| ensembl | rs3755351 |
| geneview | rs3755351 |
| scholar | rs3755351 |
| rs3755351 | |
| pharmgkb | rs3755351 |
| gwascentral | rs3755351 |
| openSNP | rs3755351 |
| 23andMe | rs3755351 |
| SNPshot | rs3755351 |
| SNPdbe | rs3755351 |
| MSV3d | rs3755351 |
| GWAS Ctlg | rs3755351 |
| GMAF | 0.3448 |
| Max Magnitude | 0 |
| ? | (A;A) (A;C) (C;C) | 28 |
|---|---|---|
|
| ||
rs3755351, a SNP in the ADD2 gene, was associated with risk for hypertension in a study involving 1,500+ Japanese patients. The odds ratio associated with the risk allele, rs3755351(C), which is also the most common allele, is 1.30 (CI: 1.15 - 1.46, p = 0.00002). [PMID 18003638]
Note that a neighboring ADD2 SNP in close (r2 of 0.806) proximity, rs17006246, was associated with hypertension in a diabetes study [PMID 17463246]; however, in this case, it was in "the opposite direction of effect". This discrepancy has not been resolved. [PMID 18003638]
