|(A;G)||1.2||Increased risk of myocardial infarction in women|
|(G;G)||1.2||Less susceptible to autoimmune thyroid diseases, but women more susceptible to myocardial infarction|
[PMID 27556446] TNFSF4 Gene Variations Are Related to Early-Onset Autoimmune Thyroid Diseases and Hypothyroidism of Hashimoto's Thyroiditis. (2016 article) "An association between GG genotype of rs3850641 in TNFSF4 gene and AITDs was found (p = 0.046). Additionally, the clinical sub-phenotype analysis revealed a significant association between GG genotype in rs7514229 and AITDs patients who were ≤18 years of age. Furthermore, rs3850641 variant allele G was in strong association with hypothyroidism in Hashimoto’s thyroiditis (HT) (p = 0.018)." (Abstract). ... "Further analysis found that the frequencies of TT genotype in rs7514229 and GG genotype in rs3850641 were lower in the AITDs group than the control group (Table 3), which suggested that people with these genotypes are less susceptible to AITDs (p = 0.016, OR = 0.236, 95% CI = 0.066–0.850 and p = 0.027, OR = 0.492, 95% CI = 0.259–0.935, respectively)."
[PMID 18998106] Genetic variants of TNFSF4 and risk for carotid artery disease and stroke. Participants were genotyped for the rs3850641 SNP in TNFSF4. Genotype associations were neither found with TNFSF4 mRNA levels nor with atherosclerosis associated systemic factors or risk for stroke.
[PMID 21402531] [Association study between TNFSF4 and coronary heart disease]
[PMID 15750594] Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility. (2005 article). "In two independent human populations, the less common allele of SNP rs3850641 in TNFSF4 was significantly more frequent (P <or= 0.05) in individuals with myocardial infarction than in controls." (Abstract)
[PMID 17767904] Genetic and genomic insights into the molecular basis of atherosclerosis.
[PMID 18356244] Genetic variants of tumor necrosis factor superfamily, member 4 (TNFSF4), and risk of incident atherothrombosis and venous thromboembolism.
[PMID 18430236] Genetic and functional association of FAM5C with myocardial infarction.
[PMID 21445270] A common polymorphism in the promoter region of the TNFSF4 gene is associated with lower allele-specific expression and risk of myocardial infarction. (2011 article) "The rs45454293T-allele, in agreement with the linked rs3850641G-allele, proved to be associated with increased risk of MI in women."
[PMID 21476935] Association of OX40 and OX40L gene polymorphisms with acute coronary syndrome in a Han Chinese population.
[PMID 23184501] TNFSF4 gene polymorphism rs3861950 but not rs3850641 is associated with the risk of cerebral infarction in a Chinese population
[PMID 22870213] Association of OX40L polymorphisms with sporadic breast cancer in northeast Chinese Han population.
[PMID 23216302] Genetic variation in the OX40L/OX40 system and plasma lipid and lipoprotein levels in a Chinese hypertriglyceridemic population.
[PMID 26814870] [Association between tumor necrosis factor superfamily member 4 gene polymorphism and risk of asymptomatic carotid vulnerable plaque in a Chinese population].