rs4129148
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 3 | >3x risk of schizophrenia |
| (C;G) | 2 | 3x risk of schizophrenia. |
| (G;G) | common |
| Reference | GRCh38 38.1/141 |
| Chromosome | X |
| Position | 1029445 |
| Gene | CSF2RA |
| is a | snp |
| is | mentioned by |
| dbSNP | rs4129148 |
| dbSNP (classic) | rs4129148 |
| ClinGen | rs4129148 |
| ebi | rs4129148 |
| HLI | rs4129148 |
| Exac | rs4129148 |
| Gnomad | rs4129148 |
| Varsome | rs4129148 |
| LitVar | rs4129148 |
| Map | rs4129148 |
| PheGenI | rs4129148 |
| Biobank | rs4129148 |
| 1000 genomes | rs4129148 |
| hgdp | rs4129148 |
| ensembl | rs4129148 |
| geneview | rs4129148 |
| scholar | rs4129148 |
| rs4129148 | |
| pharmgkb | rs4129148 |
| gwascentral | rs4129148 |
| openSNP | rs4129148 |
| 23andMe | rs4129148 |
| SNPshot | rs4129148 |
| SNPdbe | rs4129148 |
| MSV3d | rs4129148 |
| GWAS Ctlg | rs4129148 |
| GMAF | 0.4587 |
| Max Magnitude | 3 |
| ? | (C;C) (C;G) (G;G) | 28 |
|---|---|---|
|
| ||
Located in the Pseudoautosomal region
rs4129148, located near the CSF2RA gene, has been reported in a whole genome association study to be associated with schizophrenia.
The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with this allele is 3.23 (CI 2.04 - 5.15). [PMID 17522711]
| GWAS | |
|---|---|
| SNP | rs4129148 |
| PubMedID | [PMID 17522711] |
| Condition | Schizophrenia |
| Gene | CSF2RA,IL3RA |
| Risk Allele | C |
| pValue | 4.00E-007 |
| OR | 3.23 |
| 95% CI | 2.04-5.15 |
[PMID 19197363
] A genome-wide investigation of SNPs and CNVs in schizophrenia.
[PMID 19844207] Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample.
[PMID 20485477] New Genetic Findings in Schizophrenia: Is there Still Room for the Dopamine Hypothesis of Schizophrenia?
Given the results from the recent massive Psychiatric Genomics Consortium GWAS, it appears very unlikely that any large effect common SNPs exist for schizophrenia. It is not completely clear, though, how the previously replicated results for rs4129148 might be explained. It is currently predicted that 10,000 SNPs contribute to schizophrenic illness.
The diagnosis for schizophrenia has now possibly shifted from asking: Schizophrenic? Yes or No to How much Schizophrenic?
[PMID 25056061] Biological insights from 108 schizophrenia-associated genetic loci.
