||slightly increased risk for celiac disease
||slightly decreased risk for celiac disease
rs4686484 is a SNP in the LPP gene. The LPP protein is involved in cell motility and cell–cell adhesion, which is crucial to maintaining the barrier integrity of epithelial monolayers such as those in the small intestine.
A study of several populations eventually settled on rs4686484 as the SNP most likely to be the functional variant at the heart of the haplotypes associated with altered risk for celiac disease. The rarer rs4686484(G) allele is less common in patients than in healthy controls, and it is therefore thought to have a (slight) protective role, leading to reduced risk for the disorder.[PMID 24334606]