rs4846914
| Orientation | plus |
| Stabilized | plus |
| Make rs4846914(A;A) |
| Make rs4846914(A;G) |
| Make rs4846914(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 1 |
| Position | 230159944 |
| Gene | GALNT2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs4846914 |
| dbSNP (classic) | rs4846914 |
| ClinGen | rs4846914 |
| ebi | rs4846914 |
| HLI | rs4846914 |
| Exac | rs4846914 |
| Gnomad | rs4846914 |
| Varsome | rs4846914 |
| LitVar | rs4846914 |
| Map | rs4846914 |
| PheGenI | rs4846914 |
| Biobank | rs4846914 |
| 1000 genomes | rs4846914 |
| hgdp | rs4846914 |
| ensembl | rs4846914 |
| geneview | rs4846914 |
| scholar | rs4846914 |
| rs4846914 | |
| pharmgkb | rs4846914 |
| gwascentral | rs4846914 |
| openSNP | rs4846914 |
| 23andMe | rs4846914 |
| SNPshot | rs4846914 |
| SNPdbe | rs4846914 |
| MSV3d | rs4846914 |
| GWAS Ctlg | rs4846914 |
| GMAF | 0.3673 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
| GWAS | |
|---|---|
| SNP | rs4846914 |
| PubMedID | [PMID 18193044 ]
|
| Condition | Triglycerides |
| Gene | GALNT2 |
| Risk Allele | G |
| pValue | 7.00E-015 |
| OR | 0.08 |
| 95% CI | 0.06-0.10) % SD highe |
| GWAS snp | |
|---|---|
| PMID | [PMID 19060906]
|
| Trait | HDL cholesterol |
| Title | Common variants at 30 loci contribute to polygenic dyslipidemia |
| Risk Allele | G |
| P-val | 4E-8 |
| Odds Ratio | 0.05 [0.01-0.09] SD decrease |
[PMID 19656773] A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia
The G allele of rs4846914 is associated with higher risk of hypertriglyceridemia. [PMID 18596051]]
[PMID 21933382] Association of the GALNT2 gene polymorphisms and several environmental factors with serum lipid levels in the Mulao and Han populations
| GWAS snp | |
|---|---|
| PMID | [PMID 20686565]
|
| Trait | |
| Title | Biological, clinical and population relevance of 95 loci for blood lipids. |
| Risk Allele | G |
| P-val | 4E-21 |
| Odds Ratio | 0.6100 None |
[PMID 18852197] Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.
[PMID 18987386] Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population.
[PMID 19041386] Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.
[PMID 19060910] Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
[PMID 19197348] Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
[PMID 19299407] Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample.
[PMID 19951432] Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.
[PMID 20158509] Triglyceride level modifying functional variants of GALTN2 and MLXIPL in patients with ischaemic stroke.
[PMID 20160193] Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples.
[PMID 20385826] Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).
| GWAS snp | |
|---|---|
| PMID | [PMID 24097068]
|
| Trait | HDL cholesterol |
| Title | Discovery and refinement of loci associated with lipid levels. |
| Risk Allele | G |
| P-val | 4E-41 |
| Odds Ratio | .05 [NR] unit decrease |
[PMID 26405973] Gene environment interaction of GALNT2 and APOE gene with hypertension in the Chinese Han Population
[PMID 33171515] GALNT2 Gene Variant rs4846914 Is Associated with Insulin and Insulin Resistance Depending on BMI in PCOS Patients: a Case-Control Study.
