|(C;C)||1||0.73x decreased risk for colorectal cancer|
|(C;T)||1||0.86x decreased risk for colorectal cancer|
|(T;T)||1.5||1x risk for colorectal cancer|
|?||(C;C) (C;T) (T;T)||28|
rs4939827 is one of 3 SNPs in the SMAD7 gene associated with risk for colorectal cancer, based on a large study (7,400+ cases) conducted in the UK. The odds ratios show a decreased risk for the minor rs4939827(C) allele; the OR for (C;C) homozygotes is 0.73 (CI: 0.66-0.8), and for (C;T) heterozygotes 0.86 (CI: 0.79-0.92), overall p=1x10-12.[PMID 17934461]
|Title||Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21|
|Odds Ratio||1.20 [1.16-1.24]|
|Title||A genome-wide association study identifies colorectal cancer susceptibility loci on chromosome 10p14 and 8q23.3|
|Odds Ratio||1.18 [1.10-1.25]|
|Desc||MOTHERS AGAINST DECAPENTAPLEGIC, DROSOPHILA, HOMOLOG OF, 7; SMAD7|
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|Odds Ratio||1.1400 [1.08-1.18]|
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|Odds Ratio||1.12 [1.09-1.16]|
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|Disease||Colorectal cancer 3|
|CLNDBN||Colorectal cancer 3|
|CLNSRC||OMIM Allelic Variant|
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