rs560887
Orientation | minus |
Stabilized | minus |
Geno | Mag | Summary |
---|---|---|
(A;A) | 2 | Avg. fasting Plasma Glucose 5.06 mmol/L (91 mg/dl). |
(A;G) | 2 | Avg. fasting Plasma Glucose 5.12 mmol/L (92 mg/dl). |
(G;G) | 2.1 | Avg. fasting Plasma Glucose 5.18 mmol/L (93 mg/dl). |
Reference | GRCh37 37.1/131 |
Chromosome | 2 |
Position | 168906638 |
Gene | G6PC2 |
is a | snp |
is | mentioned by |
dbSNP | rs560887 |
dbSNP (classic) | rs560887 |
ClinGen | rs560887 |
ebi | rs560887 |
HLI | rs560887 |
Exac | rs560887 |
Gnomad | rs560887 |
Varsome | rs560887 |
LitVar | rs560887 |
Map | rs560887 |
PheGenI | rs560887 |
Biobank | rs560887 |
1000 genomes | rs560887 |
hgdp | rs560887 |
ensembl | rs560887 |
geneview | rs560887 |
scholar | rs560887 |
rs560887 | |
pharmgkb | rs560887 |
gwascentral | rs560887 |
openSNP | rs560887 |
23andMe | rs560887 |
SNPshot | rs560887 |
SNPdbe | rs560887 |
MSV3d | rs560887 |
GWAS Ctlg | rs560887 |
GMAF | 0.1515 |
Max Magnitude | 2.1 |
? | (A;A) (A;G) (G;G) | 28 |
---|---|---|
|
[PMID 18451265] rs560887, p = 4 x 10(-7))
- 654 normoglycemic subjects, replicated in 9,353 subjects
- fasting plasma glucose (FPG) (beta = -0.06 mmol/l per A-allele, combined p = 4 x 10(-23)) and with pancreatic beta-cell function (Homa-B model, combined p = 3 x 10(-13)) in three populations; however it was not associated with type 2 diabetes risk.
GWAS | |
---|---|
SNP | rs560887 |
PubMedID | [PMID 18451265] |
Condition | Fasting plasma glucose |
Gene | G6PC2 |
Risk Allele | A |
pValue | 4.00E-023 |
OR | 0.06 |
95% CI | 0.05-0.08) mmol/l decreas |
GWAS snp | |
---|---|
PMID | [PMID 19060910] |
Trait | Other metabolic traits |
Title | Genome-wide association analysis of metabolic traits in a birth cohort from a founder population |
Risk Allele | A |
P-val | 6E-10 |
Odds Ratio | 0.06 [0.04-0.07] mmol/l decrease |
GWAS snp | |
---|---|
PMID | [PMID 19060907] |
Trait | Fasting plasma glucose |
Title | Variants in MTNR1B influence fasting glucose levels |
Risk Allele | C |
P-val | 1E-57 |
Odds Ratio | 0.06 [0.05-0.07] mmol/l increase |
[PMID 19651812] Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type-2 diabetes amongst Indian Asians and European whites
[PMID 19741166] Common Genetic Determinants of Glucose Homeostasis in Healthy Children: The European Youth Heart Study (EYHS)
[PMID 20029179] Association of a Common G6PC2 Variant with Fasting Plasma Glucose Levels in Non-Diabetic Individuals
GWAS snp | |
---|---|
PMID | [PMID 20081858] |
Trait | Fasting glucose-related traits |
Title | New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk |
Risk Allele | C |
P-val | 2E-66 |
Odds Ratio | None None |
[PMID 20826583] The Impact of Genetic Variation in the G6PC2 Gene on Insulin Secretion Depends on Glycemia
[PMID 20839289] Impact of repeated measures and sample selection on genome-wide association studies of fasting glucose
[PMID 21036910] Association of a fasting glucose genetic risk score with subclinical atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) Study
GWAS snp | |
---|---|
PMID | [PMID 22508271] |
Trait | |
Title | Fasting glucose GWAS candidate region analysis across ethnic groups in the Multiethnic Study of Atherosclerosis (MESA). |
Risk Allele | T |
P-val | 0.000002 |
Odds Ratio | 1.2900 None |
GWAS snp | |
---|---|
PMID | [PMID 22399527] |
Trait | |
Title | Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. |
Risk Allele | G |
P-val | 5E-26 |
Odds Ratio | 0.1500 None |
GWAS snp | |
---|---|
PMID | [PMID 22286219] |
Trait | |
Title | Genome-wide association study identifies multiple loci influencing human serum metabolite levels. |
Risk Allele | |
P-val | 2E-17 |
Odds Ratio | 0.1500 None |
[PMID 18521185] Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.
[PMID 18984742] A single-nucleotide polymorphism in a methylatable Foxa2 binding site of the G6PC2 promoter is associated with insulin secretion in vivo and increased promoter activity in vitro.
[PMID 19096518] Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.
[PMID 19533084] Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk.
[PMID 19669124] A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads.
[PMID 19741163] Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose.
[PMID 19937311] Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations.
[PMID 20043853] Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.
[PMID 20622168] Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels.
[PMID 20628598] Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects.
[PMID 20870969] Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study. (ageing)
GWAS snp | |
---|---|
PMID | [PMID 22581228] |
Trait | |
Title | A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. |
Risk Allele | |
P-val | 2E-113 |
Odds Ratio | None None |
[PMID 23508304] Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels
GWAS snp | |
---|---|
PMID | [PMID 22916037] |
Trait | Metabolite levels |
Title | Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis. |
Risk Allele | |
P-val | 4E-15 |
Odds Ratio | NR NR |
[PMID 23840762] Large Scale Meta-Analyses of Fasting Plasma Glucose Raising Variants in GCK, GCKR, MTNR1B and G6PC2 and Their Impacts on Type 2 Diabetes Mellitus Risk
[PMID 22438186] A SNP in G6PC2 predicts insulin secretion in type 1 diabetes
GWAS snp | |
---|---|
PMID | [PMID 23903356] |
Trait | Glycemic traits (pregnancy) |
Title | Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies. |
Risk Allele | T |
P-val | 2E-16 |
Odds Ratio | .01 [NR] unit decrease |
[PMID 22486180] HbA1c-based diabetes diagnosis among patients with glucokinase mutation (GCK-MODY) is affected by a genetic variant of glucose-6-phosphatase (G6PC2).
[PMID 22698489] Nonfasting glucose, ischemic heart disease, and myocardial infarction: a Mendelian randomization study.
GWAS snp | |
---|---|
PMID | [PMID 24405752] |
Trait | Glycated hemoglobin levels |
Title | Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects: the Long Life Family Study (LLFS). |
Risk Allele | T |
P-val | 1E-17 |
Odds Ratio | .03 [0.024-0.040] unit decrease |