| Geno
|
Mag
|
Summary
|
| (C;C)
|
0
|
normal
|
| (C;T)
|
|
higher insulinogenic index in obese children
|
| (T;T)
|
|
higher insulinogenic index in obese children
|
rs573225 is a SNP in the glucose-6-phosphatase, catalytic, 2 G6PC2 gene.
Based on a study of 734 young European children with obesity, the insulinogenic index (IGI) of insulin secretion was determined to be associated with rs573225 by linear regression analysis and was 30% greater in (T;T) or (C;T) genotypes than in (C;C) obese children (alleles oriented with respect to dbSNP). rs573225 was also associated with fasting glucose. [PMID 18984742
]
[PMID 19060907] Variants in MTNR1B influence fasting glucose levels.
[PMID 20622168] Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels.
[PMID 23508304] Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels
]
