rs603965
Merged into | rs9344 |
Orientation | plus |
Stabilized | plus |
Geno | Mag | Summary |
---|---|---|
(A;A) | 0 | normal |
(A;G) | ? | |
(G;G) | increased breast cancer risk |
Reference | GRCh38 38.1/141 |
Chromosome | 11 |
Position | 69648142 |
Gene | CCND1, LOC100996515 |
is a | snp |
is | mentioned by |
dbSNP | rs603965 |
dbSNP (classic) | rs603965 |
ClinGen | rs603965 |
ebi | rs603965 |
HLI | rs603965 |
Exac | rs603965 |
Gnomad | rs603965 |
Varsome | rs603965 |
LitVar | rs603965 |
Map | rs603965 |
PheGenI | rs603965 |
Biobank | rs603965 |
1000 genomes | rs603965 |
hgdp | rs603965 |
ensembl | rs603965 |
geneview | rs603965 |
scholar | rs603965 |
rs603965 | |
pharmgkb | rs603965 |
gwascentral | rs603965 |
openSNP | rs603965 |
23andMe | rs603965 |
SNPshot | rs603965 |
SNPdbe | rs603965 |
MSV3d | rs603965 |
GWAS Ctlg | rs603965 |
Status | Merged into rs9344 |
Max Magnitude | 0 |
? | (A;A) (A;G) (G;G) | 28 |
---|---|---|
|
rs603965 is a SNP in the cyclin D1 CCND1 gene. It is also known as Pro241Pro. The associated genotypes are characterized in terms of their enzymatic activity as High for (A;A), Medium (A;G), and Low (G;G).
In a study of 2 populations of breast cancer patients (2,000+ patients), increased risk was associated with rs603965(A;A) genotypes in both the Ontario [odds ratio 2.22, CI: 1.49-3.28] and Finland [OR 1.73, CI: 1.08-2.78] populations.[PMID 18194538]
GWAS snp | |
---|---|
PMID | [PMID 23502783] |
Trait | Multiple myeloma (IgH translocation) |
Title | The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. |
Risk Allele | G |
P-val | 2E-11 |
Odds Ratio | 1.95 [1.61-2.38] |
[PMID 24264314] Association between CCND1 and XPC polymorphisms and bladder cancer risk: a meta-analysis based on 15 case-control studies
[PMID 27156331] SNP rs1059234 in CDKN1A Gene Correlates with Prognosis in Resected Gastric Adenocarcinoma.
[PMID 28380465] Impact of interaction between the G870A and EFEMP1 gene polymorphism on glioma risk in Chinese Han population.