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rs61729907

From SNPedia

Orientationplus
Stabilizedplus
Make rs61729907(A;A)
Make rs61729907(A;G)
Make rs61729907(G;G)
ReferenceGRCh38 38.7/150
Chromosome19
Position9214576
GeneOR7D4
is asnp
is mentioned by
dbSNPrs61729907
dbSNP (classic)rs61729907
ClinGenrs61729907
ebirs61729907
HLIrs61729907
Exacrs61729907
Gnomadrs61729907
Varsomers61729907
LitVarrs61729907
Maprs61729907
PheGenIrs61729907
Biobankrs61729907
1000 genomesrs61729907
hgdprs61729907
ensemblrs61729907
geneviewrs61729907
scholarrs61729907
googlers61729907
pharmgkbrs61729907
gwascentralrs61729907
openSNPrs61729907
23andMers61729907
23andMe allrs61729907
SNPshotrs61729907
SNPdbers61729907
MSV3drs61729907
GWAS Ctlgrs61729907
GMAF0.1476
Max Magnitude0

rs61729907 is a SNP in the OR7D4 olfactory receptor gene. This SNP causes a change at amino acid 88 of the OR7D4 protein from Arginine to Tryptophan (R88W or Arg88Trp).


[PMID 17873857] Genetic variation in a human odorant receptor alters odour perception.
A common variant of the receptor OR7D4, OR7D4 WM contains two non-synonymous single nucleotide polymorphisms (SNPs), resulting in two amino acid substitutions (R88W, T133M; hence 'RT') that severely impair function in vitro. Human subjects with RT/WM or WM/WM genotypes as a group were less sensitive to androstenone and androstadienone and found both odours less unpleasant than the RT/RT group.


[PMID 22362865OA-icon.png] A genome-wide study on the perception of the odorants androstenone and galaxolide.
Replicated the previously reported association between perception of androstenone and OR7D4 and revealed that individuals with homozygous mutations in rs61729907 impaired androstenone perception