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From SNPedia

Geno Mag Summary
(A;A) 2.6 introversion; depression resistant; impaired motor skills learning; somewhat quicker mental decline in Alzheimer patients
(A;G) 2.6 Slightly increased risk for ADHD or depression; somewhat quicker mental decline in Alzheimer patients
(G;G) 0 common/normal
ReferenceGRCh38 38.1/142
is asnp
is mentioned by
dbSNP (classic)rs6265
1000 genomesrs6265
GWAS Ctlgrs6265
Max Magnitude2.6
? (A;A) (A;G) (G;G) 28

rs6265, also known as Val66Met, is a SNP in brain-derived neurotrophic factor BDNF gene. The more common G allele encodes the Val, while the A allele encodes Met.

The A allele may also be protective against depression when subjected to repeated defeat [PMID 17956738] g2b2mh blog

On a driving-based motor learning task subjects with this genotype showed greater error during short-term learning and poorer retention over 4 days, relative to subjects without the polymorphism. The presence of this BDNF polymorphism is associated with differences in brain motor system function, altered short-term plasticity, and greater error in short-term motor learning. [PMID 19745020OA-icon.png]

A 2017 study of 1,000 Alzheimer's disease patients, a third of whom were rs6265(A) carriers, concluded that over the ~7 year study such carriers lost memory and thinking skills somewhat more rapidly than non-carriers.10.​1212/​WNL.​0000000000003980

Wired discusses the research as does 23andMe blog.

[PMID 25288136OA-icon.png] Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. [PMID 20042999OA-icon.png] Met/A allele associated with introversion

[PMID 17293537OA-icon.png] Alzheimer's disease risk for non ApoE4 carriers is affected by the heterozygous form of rs6265, as well as the diplotypes of rs6265, rs11030104, and rs2049045.

[PMID 18600033] Depressed patients who had (GA or AA) appeared to show a significantly increased risk of suicidal behaviour

[PMID 19209189OA-icon.png] In 2 studies of British women, rs6265(A;A) women had a lower body mass index than rs6265(G) allele carriers, with the difference being -0.57-0.911 kg/m(2), depending on the study.

[PMID 19388013OA-icon.png] BDNF, relative preference, and reward circuitry responses to emotional communication

GWAS snp
PMID [PMID 19079260]
Trait Body mass index
Title Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
Risk Allele G
P-val 5E-10
Odds Ratio 4.58 [3.07-6.09] % SD

[PMID 19461660] No association between the brain-derived neurotrophic factor gene and panic disorder in Japanese population

[PMID 19530966] Development of a new genotyping assay for detection of the BDNF Val66Met polymorphism using melting-curve analysis

[PMID 19603419] Meta-analysis of brain-derived neurotrophic factor p.Val66Met in adult ADHD in four European populations

[PMID 20943059] Attention-deficit hyperactivity disorder and intellectual disability: a study of association with brain-derived neurotrophic factor gene polymorphisms

[PMID 15940292] A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication

[PMID 18286632] Association study of brain-derived neurotrophic factor (BDNF) and LIN-7 homolog (LIN-7) genes with adult attention-deficit/hyperactivity disorder


[PMID 19699537] Family-based association study between brain-derived neurotrophic factor gene and major depressive disorder of Chinese descent

[PMID 19925205] Ebbinghaus Revisited: Influences of the BDNF Val66Met Polymorphism on Backward Serial Recall Are Modulated by Human Aging

[PMID 20033742] Genetic association of the interaction between the BDNF and GSK3B genes and major depressive disorder in a Chinese population

[PMID 19895626] The effect of BDNF gene variants on asthma in German children

[PMID 20087404OA-icon.png] Genetic variants in the BDNF gene and therapeutic response to risperidone in schizophrenia patients: a pharmacogenetic study

[PMID 20147969] Non-synonymous single-nucleotide polymorphisms associated with blood pressure and hypertension

[PMID 20418890OA-icon.png] Genome-wide meta-analyses identify multiple loci associated with smoking behavior

[PMID 20682308] The combined effects of the BDNF and GSK3B genes modulate the relationship between negative life events and major depressive disorder

[PMID 20456319] Association of polymorphisms in the BDNF, DRD1 and DRD3 genes with tobacco smoking in schizophrenia

[PMID 20702703OA-icon.png] The Role of the BDNF Val66Met Polymorphism for the Synchronization of Error-Specific Neural Networks

[PMID 20959432] BDNF and CGRP interaction: Implications in migraine susceptibility

[PMID 20966902OA-icon.png] Genome-Wide Association Study of Anthropometric Traits and Evidence of Interactions With Age and Study Year in Filipino Women

[PMID 21188787] Brain-derived neurotrophic factor gene polymorphisms: influence on treatment response phenotypes of major depressive disorder

[PMID 20843981OA-icon.png] Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children

[PMID 21300947] The Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Prediction of Neural Risk for Alzheimer Disease


[PMID 21723144] Genetic variation in BDNF is associated with allergic asthma and allergic rhinitis in an ethnic Chinese population in Singapore

[PMID 21796141] Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area

[PMID 21527513] Influence of physical inactivity on associations between single nucleotide polymorphisms and genetic predisposition to childhood obesity

[PMID 21889574] Association analysis between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and treatment response to venlafaxine XR in generalized anxiety disorder

[PMID 21980924OA-icon.png] BDNF Val66Met and Cognition: All, None, or Some? A Meta-Analysis of the Genetic Association

[PMID 22033217] Interaction between BDNF Val66Met and childhood stressful life events is associated to affective memory bias in men but not women

[PMID 22085476] Evidence of associations between bipolar disorder and the brain-derived neurotrophic factor (BDNF) gene

[PMID 22127997] No association of brain-derived neurotrophic factor Val66Met polymorphism with anorexia nervosa in Japanese

[PMID 22173577] Recapitulation of the Association of the Val66Met Polymorphism of BDNF Gene With BMI in Koreans

[PMID 22188054OA-icon.png] Polymorphisms in the Brain Derived Neurotrophic Factor (BDNF) Gene Influence Memory and Processing Speed One Month After Brain Injury

[PMID 22194877OA-icon.png] Brain Derived Neurotrophic Factor (BDNF) Expression Is Regulated by MicroRNAs miR-26a and miR-26b Allele-Specific Binding

[PMID 21641949] Functional variants of the genes involved in neurodevelopment and susceptibility to schizophrenia in an Armenian population

[PMID 21880305] The brain-derived neurotrophic factor is associated with alcohol dependence-related depression and antidepressant response

[PMID 22548711] Association of BDNF Gene Polymorphism with Bipolar Disorders in Han Chinese Population

[PMID 22719849OA-icon.png] Impact of Brain-Derived Neurotrophic Factor Val66Met Polymorphism on Cortical Thickness and Voxel-Based Morphometry in Healthy Chinese Young Adults

[PMID 22766130OA-icon.png] BDNF Val66Met and spontaneous dyskinesias in non-clinical psychosis

Risk Rs6265(A;A)
Alt Rs6265(A;A)
Reference Rs6265(G;G)
Significance Other
Disease Memory impairment Obsessive-compulsive disorder Anorexia nervosa 2 Bulimia nervosa 2 Bipolar affective disorder Parkinson disease not specified
Variation info
CLNDBN Memory impairment, susceptibility to Obsessive-compulsive disorder, protection against Anorexia nervosa 2 Bulimia nervosa 2 Bipolar affective disorder, susceptibility to Parkinson disease not specified
Reversed 1
HGVS NC_000011.9:g.27679916C>T
CLNSRC OMIM Allelic Variant
CLNACC RCV000019267.3, RCV000019268.2, RCV000019269.3, RCV000019270.3, RCV000019271.3, RCV000019272.3, RCV000155463.2,

[PMID 12836135OA-icon.png] Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder.

[PMID 15457498] Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder.

[PMID 16005437] Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression.

[PMID 16497333] No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults.

[PMID 16631352] No association between the brain-derived neurotrophic factor gene and schizophrenia in a Japanese population.

[PMID 16741941] Transmission distortion of BDNF variants to bipolar disorder type I patients from a South American population isolate.

[PMID 16962786] Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease.

[PMID 17096834OA-icon.png] No association between polymorphisms in the BDNF gene and age at onset in Huntington disease.

[PMID 17135278OA-icon.png] Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs.

[PMID 17196936] Brain-derived neurotrophic factor and risk of schizophrenia: an association study and meta-analysis.

[PMID 17212826OA-icon.png] TAMGeS: a Three-array Method for Genotyping of SNPs by a dual-colour approach.

[PMID 17219016] No evidence for preferential transmission of common valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor gene (BDNF) in ADHD.

[PMID 17417060] Meta-analysis reveals no association of the Val66Met polymorphism of brain-derived neurotrophic factor with either schizophrenia or bipolar disorder.

[PMID 17483451OA-icon.png] Gene-gene interaction associated with neural reward sensitivity.

[PMID 17503330OA-icon.png] A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence.

[PMID 17602759] Immune cell BDNF secretion is associated with white matter volume in multiple sclerosis.

[PMID 17632285OA-icon.png] The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans.

[PMID 17656372] Preservation of gray matter volume in multiple sclerosis patients with the Met allele of the rs6265 (Val66Met) SNP of brain-derived neurotrophic factor.

[PMID 17657167] Lack of association between the BDNF gene Val66Met polymorphism and Alzheimer disease in a Chinese Han population.

[PMID 17894414OA-icon.png] BDNF Val66Met variant and age of onset in schizophrenia.

[PMID 17918236] Association study of the brain-derived neurotropic factor (BDNF) gene in attention deficit hyperactivity disorder.

[PMID 18205169] Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis.

[PMID 18478177] Investigation of the functional brain-derived neurotrophic factor gene variant Val66MET in migraine.

[PMID 18534558OA-icon.png] Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence.

[PMID 18565990OA-icon.png] Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence.

[PMID 18698231OA-icon.png] Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.

[PMID 18704161OA-icon.png] Genetic variation in an individual human exome.

[PMID 18776599OA-icon.png] Susceptibility genes for gentamicin-induced vestibular dysfunction.

[PMID 18813964OA-icon.png] Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta.

[PMID 18830724OA-icon.png] Assessment of Alzheimer's disease case-control associations using family-based methods.

[PMID 18852698] Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity.

[PMID 18957941OA-icon.png] Genome-wide association scan for five major dimensions of personality.

[PMID 19018231OA-icon.png] Evidence of association between brain-derived neurotrophic factor gene and bipolar disorder.

[PMID 19018715] Association studies of the BDNF and the NTRK2 gene polymorphisms with prophylactic lithium response in bipolar patients.

[PMID 19236730] Brain-derived neurotrophic factor ( BDNF) gene: no major impact on antidepressant treatment response.

[PMID 19258022OA-icon.png] Now or Later? An fMRI study of the effects of endogenous opioid blockade on a decision-making network.

[PMID 19295238] Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic families.

[PMID 19330778] Positive association between the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder in the Han Chinese population.

[PMID 19336781OA-icon.png] Molecular differentiation of schizoaffective disorder from schizophrenia using BDNF haplotypes.

[PMID 19359258OA-icon.png] Cohort profile: risk patterns and processes for psychopathology emerging during adolescence: the ROOTS project.

[PMID 19412541OA-icon.png] Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects.

[PMID 19424874] Effect of BDNF Val66Met polymorphism on digital working memory and spatial localization in a healthy Chinese Han population.

[PMID 19478790OA-icon.png] The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.

[PMID 19582215OA-icon.png] Association study between BDNF gene polymorphisms and autism by three-dimensional gel-based microarray.

[PMID 19582565OA-icon.png] Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder.

[PMID 19721723OA-icon.png] Brain-derived neurotrophic factor: role in depression and suicide.

[PMID 19721846OA-icon.png] Candidate genes involved in neural plasticity and the risk for attention-deficit hyperactivity disorder: a meta-analysis of 8 common variants.

[PMID 19844571OA-icon.png] Variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, are associated with memory and general cognitive abilities.

[PMID 19940176OA-icon.png] Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humans.

[PMID 19953912] [An association study of brain-derived neurotrophic factor gene polymorphism in bipolar disorders].

[PMID 20004415] Serotonergic functioning as measured by the loudness dependence of auditory evoked potentials is related to a haplotype in the brain-derived neurotrophic factor (BDNF) gene.

[PMID 20008943OA-icon.png] Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study.

[PMID 20014955] Gene-gene interactions of the brain-derived neurotrophic-factor and neurotrophic tyrosine kinase receptor 2 genes in geriatric depression.

[PMID 20016225] Association of brain-derived neurotrophic factor genetic Val66Met polymorphism with severity of depression, efficacy of fluoxetine and its side effects in Chinese major depressive patients.

[PMID 20127379OA-icon.png] From monogenic to polygenic obesity: recent advances.

[PMID 20172611] Stressful life events and the brain-derived neurotrophic factor gene in bipolar disorder.

[PMID 20191112OA-icon.png] The Genetics of Anorexia Nervosa: Current Findings and Future Perspectives.

[PMID 20226536] Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort.

[PMID 20400928OA-icon.png] Genotyping the BDNF rs6265 (val66met) polymorphism by one-step amplified refractory mutation system PCR.

[PMID 20426150] Extending genetic linkage analysis to diffusion tensor images to map single gene effects on brain fiber architecture.

[PMID 20478698] Effect of Met66 allele of the BDNF rs6265 SNP on regional gray matter volumes in patients with multiple sclerosis: A voxel-based morphometry study.

[PMID 20482942] Fine-mapping of the brain-derived neurotrophic factor (BDNF) gene supports an association of the Val66Met polymorphism with episodic memory.

[PMID 20493546OA-icon.png] BDNF polymorphism rs6265 and hippocampal structure and memory performance in healthy control subjects.

[PMID 20574532OA-icon.png] Intermediate phenotypes identify divergent pathways to Alzheimer's disease.

[PMID 20712903OA-icon.png] Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.

[PMID 21037213OA-icon.png] Polymorphisms in BDNF (Val66Met) and 5-HTTLPR, morning cortisol and subsequent depression in at-risk adolescents.

[PMID 21049304OA-icon.png] Influence of candidate genes on attention problems in children: a longitudinal study.

[PMID 21097659] Interaction effect of functional variants of the BDNF and DRD2/ANKK1 gene is associated with alexithymia in healthy human subjects.

[PMID 21103954] Association between C-281A and val66met functional polymorphisms of BDNF gene and risk of recurrent major depressive disorder in Polish population.

[PMID 21167606] The role of BDNF genetic polymorphisms in bipolar disorder with psychiatric comorbidities.

[PMID 21172166OA-icon.png] Pharmacogenetics of antidepressant response.

[PMID 21215389] The CREB1-BDNF-NTRK2 pathway in depression: multiple gene-cognition-environment interactions.

[PMID 21305693] Age at onset of psychotic disorder: cannabis, BDNF Val66Met, and sex-specific models of gene-environment interaction.

[PMID 21458533] Polymorphisms of brain-derived neurotrophic factor associated with heroin dependence.

[PMID 21491204] Candidate-gene approach in posttraumatic stress disorder after urban violence: association analysis of the genes encoding serotonin transporter, dopamine transporter, and BDNF.

[PMID 21509595OA-icon.png] Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system.

[PMID 21577214] BDNF Val66Met genotype modulates the effect of childhood adversity on subgenual anterior cingulate cortex volume in healthy subjects.

[PMID 21640793] Association between Val66Met polymorphism of Brain-Derived Neurotrophic Factor (BDNF) gene and a deficiency of colour vision in alcohol-dependent male patients.

[PMID 21695421OA-icon.png] Brain-derived neurotrophic factor (BDNF) gene: a gender-specific role in cognitive function during normal cognitive aging of the MEMO-Study?

[PMID 21745335OA-icon.png] 5-HTTLPR and BDNF Val66Met polymorphisms moderate effects of stress on rumination.

[PMID 21875455] The brain-derived neurotrophic factor gene in suicidal behaviour: a meta-analysis.

[PMID 21898033OA-icon.png] Brain-derived neurotrophic factor gene polymorphisms, neurotransmitter levels, and depressive symptoms in an elderly population.

[PMID 21931317OA-icon.png] BDNF function as a potential mediator of bipolar disorder and post-traumatic stress disorder comorbidity.

[PMID 21956459] Association study of brain-derived neurotrophic factor gene polymorphisms and body weight change in schizophrenic patients under long-term atypical antipsychotic treatment.

[PMID 21996278] Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse.

[PMID 22008662] The association of the alpha-5 subunit of the nicotinic acetylcholine receptor gene and the brain-derived neurotrophic factor gene with different aspects of smoking behavior.

[PMID 22094229] Influence of BDNF variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophrenia.

[PMID 22179955OA-icon.png] Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program.

[PMID 22585743] Reduced fractional anisotropy in the uncinate fasciculus in patients with major depression carrying the met-allele of the Val66Met brain-derived neurotrophic factor genotype.

[PMID 22609366] Neurotrophic Tyrosine Kinase Polymorphism Impacts White Matter Connections in Patients with Major Depressive Disorder.

[PMID 22610920OA-icon.png] The brain-derived neurotrophic-factor (BDNF) val66met polymorphism is associated with geriatric depression: a meta-analysis.

[PMID 22642961] The role of brain-derived neurotrophic factor (BDNF) gene variants in antipsychotic response and antipsychotic-induced weight gain.

[PMID 22965830] No influence of brain-derived neurotrophic factor (BDNF) polymorphisms on treatment response in a naturalistic sample of patients with major depression

[PMID 22615781OA-icon.png] Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study

[PMID 23170235OA-icon.png] BDNF Val66Met polymorphism interacts with sex to influence bimanual motor control in healthy humans

[PMID 23269345] BDNF Val66Met homozygosity does not influence plasma BDNF levels in healthy human subjects

[PMID 23341118] Brain-derived neurotrophic factor Val66Met polymorphism and early life adversity affect hippocampal volume

[PMID 22910404] Genetic association study of the P300 endophenotype in schizophrenia

[PMID 23482723OA-icon.png] Association between the BDNF Val66Met Polymorphism and Chronicity of Depression

[PMID 23487199] BDNF val66met Polymorphism Is Associated With Age at Onset and Intensity of Symptoms of Paranoid Schizophrenia in a Polish Population

[PMID 23628854OA-icon.png] FTO predicts weight regain in the Look AHEAD clinical trial

[PMID 23712400OA-icon.png] SNP rs6265 Regulates Protein Phosphorylation and Osteoblast Differentiation and Influences BMD in Humans

[PMID 23923080OA-icon.png] Association of the brain-derived neurotrophic factor gene G196A rs6265 polymorphisms and the cognitive function and clinical symptoms of schizophrenia

[PMID 23424664OA-icon.png] Study of 11 BMI-associated loci identified in GWAS for associations with central obesity in the Chinese children

[PMID 23999029] Association study between BDNF gene variants and Mexican patients with obsessive-compulsive disorder

[PMID 23433505OA-icon.png] Genetic variation in BDNF is associated with antipsychotic treatment resistance in patients with schizophrenia

[PMID 24198753OA-icon.png] Toward a unified biological hypothesis for the BDNF Val66Met-associated memory deficits in humans: a model of impaired dendritic mRNA trafficking

[PMID 24269186] An obesity genetic risk score is associated with metabolic syndrome in Chinese children

[PMID 24399714] BDNF rs 6265 polymorphism and COMT rs 4680 polymorphism in deficit schizophrenia in Polish sample

[PMID 24567226] Brain-derived neurotrophic factor: its impact upon neuroplasticity and neuroplasticity inducing transcranial brain stimulation protocols

[PMID 23408508OA-icon.png] Obesity-susceptibility loci and the tails of the pediatric BMI distribution

[PMID 22813992] Effect of BDNF val(66)met polymorphism on declarative memory and its neural substrate: a meta-analysis.

[PMID 22844024OA-icon.png] Interaction between the BDNF gene Val/66/Met polymorphism and morning cortisol levels as a predictor of depression in adult women.

[PMID 22846907] Analysis of four genes involved in the neurodevelopment shows association of rs4307059 polymorphism in the cadherin 9/10 region with completed suicide.

[PMID 22989210OA-icon.png] Brain-derived neurotrophic factor genotype is associated with brain gray and white matter tissue volumes recovery in abstinent alcohol-dependent individuals.

[PMID 23023098] Brain-derived neurotrophic factor Val66Met polymorphism and alcohol-related phenotypes.

[PMID 23062292OA-icon.png] The brain-derived neurotrophic factor Val66Met polymorphism moderates early deprivation effects on attention problems.

[PMID 23137999OA-icon.png] The role of BDNF, NTRK2 gene and their interaction in development of treatment-resistant depression: data from multicenter, prospective, longitudinal clinic practice.

[PMID 23184535OA-icon.png] No association of genetic variants in BDNF with major depression: a meta- and gene-based analysis.

[PMID 23303061OA-icon.png] Brain-derived neurotrophic factor serum levels and genotype: association with depression during interferon-alpha treatment.

[PMID 23461616] Association between brain-derived neurothropic factor variants and asthma in Chinese Han children.

[PMID 23643991] Lack of association between brain-derived neurotrophic factor Val66Met polymorphism and body mass index change over time in healthy adults.

[PMID 23733030] Pharmacogenetics in major depression: a comprehensive meta-analysis.

[PMID 23832605] Association of BDNF gene polymorphisms with schizophrenia and clinical symptoms in a Chinese population.

[PMID 24863266] Val66Met polymorphism in the BDNF gene in children with bronchial asthma

[PMID 24993285] BDNF SNPs Are Implicated in Comorbid Alcohol Dependence in Schizophrenia But Not in Alcohol-Dependent Patients Without Schizophrenia

[PMID 25044977OA-icon.png] BDNF Val66Met genotype interacts with childhood adversity and influences the formation of hippocampal subfields

[PMID 25052186] Combined effects of the BDNF rs6265 (Val66Met) polymorphism and environment risk factors on psoriasis vulgaris

[PMID 25324022] Brain‑derived neurotrophic factor gene polymorphisms are associated with coronary artery disease‑related depression and antidepressant response

[PMID 25383981OA-icon.png] Association of Brain-Derived Neurotrophic Factor Gene Val66Met Polymorphism with Primary Dysmenorrhea

[PMID 25492288] [Impact of obesity-related gene polymorphism on risk of obesity and metabolic disorder in childhood]

[PMID 25649076] A functional brain-derived neurotrophic factor (BDNF) gene variant increases the risk of moderate-to-severe allergic rhinitis

[PMID 25650137] BDNF Val66Met and reward-related brain function in adolescents: Role for early alcohol consumption

[PMID 25660313] Meta-analysis of six genes (BDNF, DRD1, DRD3, DRD4, GRIN2B and MAOA) involved in neuroplasticity and the risk for alcohol dependence

[PMID 25670953OA-icon.png] Evidence for Association between the Brain-Derived Neurotrophic Factor Gene and Panic Disorder: A Novel Haplotype Analysis

[PMID 25681004] Brain-derived neurotrophic factor (BDNF) and neurocognitive deficits in people with schizophrenia: A meta-analysis

[PMID 25762803OA-icon.png] Circulating brain-derived neurotrophic factor concentrations and the risk of cardiovascular disease in the community

[PMID 24461776] No significant association between brain-derived neurotrophic factor gene rs6265 and cognitive function in Japanese patients with schizophrenia

[PMID 25950609] Association Between BDNF Gene Polymorphisms and Attention Deficit Hyperactivity Disorder in Korean Children

[PMID 25956254] BDNF Val66Met polymorphism and hippocampal volume in neuropsychiatric disorders: A systematic review and meta-analysis

[PMID 24733169OA-icon.png] Association of rs6265 and rs2030324 polymorphisms in brain-derived neurotrophic factor gene with Alzheimer's disease: a meta-analysis

[PMID 26115627] Single nucleotide polymorphisms in the BDNF gene and suicide in the Slovenian sample

[PMID 26117067] BDNF Val66Met polymorphism in patterns of neural activation in individuals with MDD and healthy controls

[PMID 26175754OA-icon.png] DNA methylation and single nucleotide variants in the brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) genes are associated with anxiety/depression in older women

[PMID 26326364] The BDNF Val66Met polymorphism is associated with improved performance on a visual-auditory working memory task in varsity athletes

[PMID 26401760] BDNF (Val66Met) genetic polymorphism is associated with vulnerability for methamphetamine dependence

[PMID 26432032OA-icon.png] Interaction between BDNF rs6265 Met allele and low family cohesion is associated with smaller left hippocampal volume in pediatric bipolar disorder

[PMID 26445699OA-icon.png] Genetic association of the transcription of neuroplasticity-related genes and variation in stress-coping style

[PMID 26739449OA-icon.png] Serum Brain-Derived Neurotrophic Factor is Related to Platelet Reactivity but not to Genetic Polymorphisms within BDNF Encoding Gene in Patients with Type 2 Diabetes.

[PMID 26889735OA-icon.png] BDNF rs6265 methylation and genotype interact on risk for schizophrenia.

[PMID 27103528] Association of genetic risk factors with cognitive decline: the PATH through life project.

[PMID 27647760] The relationship between polymorphisms of BDNFOS and BDNF genes and heroin addiction in the Han Chinese population.

[PMID 28387675] DNA Methylation and Tag SNPs of the BDNF Gene in Conversion of Amnestic Mild Cognitive Impairment into Alzheimer's Disease: A Cross-Sectional Cohort Study.

[PMID 28413930OA-icon.png] Relationship of Genetic Variants With Procedural Pain, Anxiety, and Distress in Children.

[PMID 28498887OA-icon.png] Sex Differences in Risk for Alzheimer's Disease Related to Neurotrophin Gene Polymorphisms: The Cache County Memory Study.

[PMID 28755387OA-icon.png] BDNF Genotype is Associated with Hippocampal Volume in Mild Traumatic Brain Injury.

[PMID 29052254] Genetic polymorphisms associated with smoking behaviour predict the risk of surgery in patients with Crohn's disease.

[PMID 29191473OA-icon.png] Dopamine receptors and BDNF-haplotypes predict dyskinesia in Parkinson's disease.

[PMID 30375508OA-icon.png] Effects of BDNF Val66Met genotype and schizophrenia familial risk on a neural functional network for cognitive control in humans.

[PMID 30519954] BDNF rs6265 (Val66Met) Polymorphism as a Risk Factor for Blepharospasm.

[PMID 31132388] Investigating the contribution of NPSR1, IL-6 and BDNF polymorphisms to depressive and anxiety symptoms in hemodialysis patients.

[PMID 30129980] The association between polymorphism of the BDNF gene and cigarette smoking in the Iranian population.

[PMID 31787925OA-icon.png] BDNF Val66Met Genetic Polymorphism Results in Poor Recovery Following Repeated Mild Traumatic Brain Injury in a Mouse Model and Treatment With AAV-BDNF Improves Outcomes.

[PMID 32351633OA-icon.png] An Analysis of Five TrkB Gene Polymorphisms in Schizophrenia and the Interaction of Its Haplotype with rs6265 BDNF Gene Polymorphism.

[PMID 32776402] Role of rs6265 BDNF polymorphisms and post-stroke dysphagia recovery-A prospective cohort study.

[PMID 33007373] Differential promoter methylation and G-712A polymorphism of brain-derived neurotrophic factor in post-traumatic stress disorder patients of Li and Han populations in Hainan province.

[PMID 33384622OA-icon.png] BDNF Gene's Role in Schizophrenia: From Risk Allele to Methylation Implications.

[PMID 33499851OA-icon.png] Association of PICK1 and BDNF variations with increased risk of methamphetamine dependence among Iranian population: a case-control study.

[PMID 31504225OA-icon.png] Interaction Between Physical Activity and Genes Related to Neurotrophin Signaling in Late-Life Cognitive Performance: The Cache County Study.