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rs6413413

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 common in complete genomics
Make rs6413413(A;T)
Make rs6413413(T;T)
ReferenceGRCh38 38.1/141
Chromosome4
Position99318127
GeneADH1B
is asnp
is mentioned by
dbSNPrs6413413
dbSNP (old)rs6413413
ClinGenrs6413413
ebirs6413413
HLIrs6413413
Exacrs6413413
Gnomadrs6413413
Varsomers6413413
Maprs6413413
PheGenIrs6413413
Biobankrs6413413
1000 genomesrs6413413
hgdprs6413413
ensemblrs6413413
gopubmedrs6413413
geneviewrs6413413
scholarrs6413413
googlers6413413
pharmgkbrs6413413
gwascentralrs6413413
openSNPrs6413413
23andMers6413413
23andMe allrs6413413
SNPshotrs6413413
SNPdbers6413413
MSV3drs6413413
GWAS Ctlgrs6413413
GMAF0.007805
Max Magnitude0

rs6413413, also known as Thr60Ser, is a SNP in the alcohol dehydrogenase 1B ADH1B gene. The rs6413413(A) allele is the more common, encoding the amino acid threonine (Thr); the quite rare rs6413413(T) allele encodes the variant serine (Ser).

On it's own, this SNP is said to explain 2.5% of the variability in the rate at which alcohol is metabolized, based on a study of 250 Spaniards.[PMID 20101753]

More significantly (in a statistical sense), this study concluded that combinations of this SNP and others were shown to affect alcohol metabolism; most of these combinations are represented by the gs211 genoset.

Note that the effects of alcohol are higher in individuals who break down (basically, detoxify) ethanol more slowly.


[PMID 17355643OA-icon.png] Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population.



[PMID 29045753] Association Between the rs1229984 Polymorphism in the Alcohol Dehydrogenase B (ADH1B) Gene and Risk for Restless Legs Syndrome.