rs6426749

plus

Geno	Mag	Summary
(G;G)	0	common in complete genomics

Make rs6426749(C;C)

Make rs6426749(C;G)

Reference

GRCh38 38.1/141

Chromosome

1

Position

22384980

is a	snp
is	mentioned by
dbSNP	rs6426749
dbSNP (classic)	rs6426749
ClinGen	rs6426749
ebi	rs6426749
HLI	rs6426749
Exac	rs6426749
Gnomad	rs6426749
Varsome	rs6426749
LitVar	rs6426749
Map	rs6426749
PheGenI	rs6426749
Biobank	rs6426749
1000 genomes	rs6426749
hgdp	rs6426749
ensembl	rs6426749
geneview	rs6426749
scholar	rs6426749
google	rs6426749
pharmgkb	rs6426749
gwascentral	rs6426749
openSNP	rs6426749
23andMe	rs6426749
SNPshot	rs6426749
SNPdbe	rs6426749
MSV3d	rs6426749
GWAS Ctlg	rs6426749

GMAF

0.2167

Max Magnitude

0

?

(C;C) (C;G) (G;G)

28

GWAS snp
PMID	[PMID 19801982 ]
Trait	Bone mineral density (hip)
Title	Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
Risk Allele	C
P-val	9E-8
Odds Ratio	0.08 [0.05-0.11] sd increase

GWAS snp
PMID	[PMID 22504420 ]
Trait
Title	Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
Risk Allele	C
P-val	0
Odds Ratio	0.1100 None

[PMID 29706346 ] An Osteoporosis Risk SNP at 1p36.12 Acts as an Allele-Specific Enhancer to Modulate LINC00339 Expression via Long-Range Loop Formation. The regulatory model proposed in this paper suggests that the rs6426749(G) allele ultimately suppresses CDC42 expression, leading to (slightly) decreased bone mineral density and thereby increased osteoporosis incidence.