rs6478108

Orientation

plus

Stabilized

plus

Make rs6478108(C;C)

Make rs6478108(C;T)

Make rs6478108(T;T)

Reference

GRCh38 38.1/141

Chromosome

9

Position

114796423

Gene

TNFSF15

is a	snp
is	mentioned by
dbSNP	rs6478108
dbSNP (classic)	rs6478108
ClinGen	rs6478108
ebi	rs6478108
HLI	rs6478108
Exac	rs6478108
Gnomad	rs6478108
Varsome	rs6478108
LitVar	rs6478108
Map	rs6478108
PheGenI	rs6478108
Biobank	rs6478108
1000 genomes	rs6478108
hgdp	rs6478108
ensembl	rs6478108
geneview	rs6478108
scholar	rs6478108
google	rs6478108
pharmgkb	rs6478108
gwascentral	rs6478108
openSNP	rs6478108
23andMe	rs6478108
SNPshot	rs6478108
SNPdbe	rs6478108
MSV3d	rs6478108
GWAS Ctlg	rs6478108

GMAF

0.3072

Max Magnitude

0

?	(C;C) (C;T) (T;T)	28

Associated with increased risk for Crohn's disease in a study of 380 Korean patients.[PMID 18422820]

This SNP is associated with greater susceptibility to leprosy in Asians, according to the 23andMe blog. The risk allele is T, and the odds ratio is 1.37.

The TNFSF15 gene encodes a cytokine protein in the tumor necrosis factor (TNF) family.

OMIM	612259
Desc	INFLAMMATORY BOWEL DISEASE 16; IBD16
Variant
Related	also

GWAS snp
PMID	[PMID 20018961]
Trait	Leprosy
Title	Genomewide Association Study of Leprosy
Risk Allele	A
P-val	3E-21
Odds Ratio	1.37 [1.28-1.46]

[PMID 17663424] TNFSF15 is an ethnic-specific IBD gene.

[PMID 18758464] Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease.

[PMID 19174806] TNFSF15 polymorphisms are associated with susceptibility to inflammatory bowel disease in a new European cohort.

[PMID 19262684] IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein.

[PMID 19543369] Comprehensive linkage and association analyses identify haplotype, near to the TNFSF15 gene, significantly associated with spondyloarthritis.

[PMID 22684480] Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFalpha

Leprosy Susceptibility

[PMID 24269700] Genetic risk and protective factors of TNFSF15 gene variants detected using single nucleotide polymorphisms in Hungarians with psoriasis and psoriatic arthritis

[PMID 25028192] Associations between TNFSF15 polymorphisms and susceptibility to ulcerative colitis and Crohn's disease: A meta-analysis

[PMID 26398853] Identification of Ten Additional Susceptibility Loci for Ulcerative Colitis Through Immunochip Analysis in Koreans

[PMID 25501099] Protective association of tumor necrosis factor superfamily 15 (TNFSF15) polymorphic haplotype with Ulcerative Colitis and Crohn's disease in an Indian population

[PMID 31615448] Candidate single nucleotide polymorphisms of irritable bowel syndrome: a systemic review and meta-analysis.