Leprosy

Leprosy was formerly a dreaded infectious disease whose victims were ostracized, but it can now be treated and cured. The 23andMe blog reports that the following SNPs are associated with altered risk of leprosy in people of Asian descent: The blog is based on the scientific article

[PMID 20018961] Genomewide association study of leprosy.

• rs9302752; C allele 1.59 odds
• rs6478108 in the TNFSF15 gene; T allele 1.37 odds
• rs3764147 in the C13orf31 gene; G allele 1.68 odds
• rs3088362 in the CCDC122 gene; A allele 1.52 odds
• rs1873613 in the LRRK2 gene; C allele 0.81 odds (only for the multibacillary form of leprosy); LRRK2 is also associated with susceptibility to Parkinson's disease
• rs602875; G allele 0.67 odds
• rs42490 in the RIPK2 gene; A allele 0.76 odds

Some other SNPs associated to leprosy, according to the GWAS catalogː

• rs77061563
• rs76886731
• rs73058713
• rs58600253
• rs16948876
• rs13220141
• rs11174812
• rs10817758
• rs10414149
• rs9567307
• rs9271100
• rs8060598
• rs8002861
• rs6863015
• rs4366152
• rs3762318
• rs2733954
• rs2275606
• rs2270368
• rs2221593
• rs2024825
• rs663743
• rs538147
• rs383592
• rs160451
• rs40457

SNPs in these genes are associated with susceptibility to leprosy [1] and other diseases:

• BATF3
• CCDC88B
• CCDC122
• COX4I1
• CYLD
• C13orf31
• DEC1
• HLA-DR
• IL12B
• IL18RAP
• IL18R1
• IL23R
• LACC1
• LOC388210
• LRRK2
• NOD2
• RAB32
• RIPK2
• RPS6KA4
• SIGLEC5
• TNFSF15

Publications

[PMID 27238287] Erratum to "Integrative analyses of leprosy susceptibility genes indicate a common autoimmune profile" [J. Dermatol. Sci. 82 (2016) 18-27.

[PMID 26844546] A Missense LRRK2 Variant Is a Risk Factor for Excessive Inflammatory Responses in Leprosy.

[PMID 26805555] Integrative analyses of leprosy susceptibility genes indicate a common autoimmune profile.

[PMID 26793196] Gene Association with Leprosy: A Review of Published Data.

[PMID 25642632] Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.

[PMID 25521227] Association of the LRRK2 genetic polymorphisms with leprosy in Han Chinese from Southwest China.

[PMID 25432815] Genetics of leprosy: Expected-and unexpected-developments and perspectives.

[PMID 25367361] NOD2 and CCDC122-LACC1 genes are associated with leprosy susceptibility in Brazilians.

[PMID 22984114] Crohn's disease susceptibility genes are associated with leprosy in the Vietnamese population.

[PMID 22019778] Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy.

[PMID 21119019] Leprosy and the human genome.

[PMID 20936290] Leprosy as a genetic disease.

[PMID 20018961] Genomewide association study of leprosy.