LRRK2
From SNPedia
is a | gene |
is | mentioned by |
Full name | leucine-rich repeat kinase 2 |
EntrezGene | 120892 |
PheGenI | 120892 |
VariationViewer | 120892 |
ClinVar | LRRK2 |
GeneCards | LRRK2 |
dbSNP | 120892 |
Diseases | LRRK2 |
SADR | 120892 |
HugeNav | 120892 |
wikipedia | LRRK2 |
LRRK2 | |
gopubmed | LRRK2 |
EVS | LRRK2 |
HEFalMp | LRRK2 |
MyGene2 | LRRK2 |
23andMe | LRRK2 |
UniProt | Q5S007 |
Ensembl | ENSG00000188906 |
OMIM | 609007 |
# SNPs | 26 |
Max Magnitude | Chromosome position | Summary | |
---|---|---|---|
i5045546 | |||
i5045553 | |||
rs10878226 | 0 | 40,223,890 | |
rs11176013 | 0 | 40,320,071 | |
rs11564148 | 0 | 40,320,099 | |
rs1491942 | 0 | 40,227,006 | |
rs281865052 | 6.5 | 40,323,255 | |
rs281865054 | 6.5 | 40,323,270 | |
rs33939927 | 6.5 | 40,310,434 | |
rs33949390 | 0 | 40,320,043 | |
rs33995883 | 1.8 | 40,346,884 | |
rs34410987 | 0 | 40,283,897 | |
rs34594498 | 2.5 | 40,252,984 | |
rs34637584 | 3 | 40,340,400 | |
rs34778348 | 0 | 40,363,526 | |
rs34805604 | 6.5 | 40,299,125 | |
rs34995376 | 6.5 | 40,310,435 | |
rs35801418 | 6.5 | 40,321,114 | |
rs35808389 | 6.5 | 40,298,488 | |
rs35870237 | 6.5 | 40,340,404 | |
rs3761863 | 0 | 40,364,850 | |
rs66737902 | 0 | 40,367,861 | |
rs7133914 | 0 | 40,309,109 | |
rs7308720 | 0 | 40,263,898 | |
rs74163686 | 6.5 | 40,309,225 | |
rs78365431 | 0 | 40,298,479 |
The LRRK2 gene encodes the leucine-rich repeat kinase 2 protein. The function of this large protein is not completely clear yet, but SNPs within this gene have been linked to neurodegenerative disease, most notably, an autosomal dominant, adult-onset form of Parkinson's disease.
SNPs within LRRK2 include:
- rs34637584, also known as G2019S
- rs34778348, also known as G2385R
- rs33949390, also known as R1628P
- rs1873613, associated with a reduced susceptibility to leprosy according to the 23andMe blog