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rs33995883

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 common/normal
(A;G) 1.8 Slight (1.8x) increase in risk for Crohn's disease
Make rs33995883(G;G)
ReferenceGRCh38.p7 38.3/150
Chromosome12
Position40346884
GeneLRRK2
is asnp
is mentioned by
dbSNPrs33995883
dbSNP (old)rs33995883
ClinGenrs33995883
ebirs33995883
HLIrs33995883
Exacrs33995883
Gnomadrs33995883
Varsomers33995883
Maprs33995883
PheGenIrs33995883
Biobankrs33995883
1000 genomesrs33995883
hgdprs33995883
ensemblrs33995883
gopubmedrs33995883
geneviewrs33995883
scholarrs33995883
googlers33995883
pharmgkbrs33995883
gwascentralrs33995883
openSNPrs33995883
23andMers33995883
23andMe allrs33995883
SNPshotrs33995883
SNPdbers33995883
MSV3drs33995883
GWAS Ctlgrs33995883
Max Magnitude1.8

rs33995883, also known as c.6241A>G, p.Asn2081Asp and N2081D, represents a variant in the LRKK2 gene on chromosome 12.

The minor allele of this SNP was initially reported as potentially associated with Parkinson's disease; however, more recent reviews as well as the current annotation in ClinVar all conclude it is benign (at least with respect to Parkinson's).

In 2018, a study of 2,000 patients with Crohn's disease found somewhat increased (~2x) risk for the disorder to be associated with rs33995883(G).10.1126/scitranslmed.aai7795