rs33995883
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0 | common/normal |
| (A;G) | 1.8 | Slight (1.8x) increase in risk for Crohn's disease |
| Make rs33995883(G;G) |
| Reference | GRCh38.p7 38.3/150 |
| Chromosome | 12 |
| Position | 40346884 |
| Gene | LRRK2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs33995883 |
| dbSNP (classic) | rs33995883 |
| ClinGen | rs33995883 |
| ebi | rs33995883 |
| HLI | rs33995883 |
| Exac | rs33995883 |
| Gnomad | rs33995883 |
| Varsome | rs33995883 |
| LitVar | rs33995883 |
| Map | rs33995883 |
| PheGenI | rs33995883 |
| Biobank | rs33995883 |
| 1000 genomes | rs33995883 |
| hgdp | rs33995883 |
| ensembl | rs33995883 |
| geneview | rs33995883 |
| scholar | rs33995883 |
| rs33995883 | |
| pharmgkb | rs33995883 |
| gwascentral | rs33995883 |
| openSNP | rs33995883 |
| 23andMe | rs33995883 |
| SNPshot | rs33995883 |
| SNPdbe | rs33995883 |
| MSV3d | rs33995883 |
| GWAS Ctlg | rs33995883 |
| Max Magnitude | 1.8 |
rs33995883, also known as c.6241A>G, p.Asn2081Asp and N2081D, represents a variant in the LRKK2 gene on chromosome 12.
The minor allele of this SNP was initially reported as potentially associated with Parkinson's disease; however, more recent reviews as well as the current annotation in ClinVar all conclude it is benign (at least with respect to Parkinson's).
In 2018, a study of 2,000 patients with Crohn's disease found somewhat increased (~2x) risk for the disorder to be associated with rs33995883(G).10.1126/scitranslmed.aai7795
