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rs34594498

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 common in clinvar
(C;T) 2.5 Slightly (~2x) higher risk of Parkinson's disease mutation, at least in Asians according to some studies
Make rs34594498(T;T)
ReferenceGRCh38 38.1/141
Chromosome12
Position40252984
GeneLRRK2
is asnp
is mentioned by
dbSNPrs34594498
dbSNP (classic)rs34594498
ClinGenrs34594498
ebirs34594498
HLIrs34594498
Exacrs34594498
Gnomadrs34594498
Varsomers34594498
LitVarrs34594498
Maprs34594498
PheGenIrs34594498
Biobankrs34594498
1000 genomesrs34594498
hgdprs34594498
ensemblrs34594498
geneviewrs34594498
scholarrs34594498
googlers34594498
pharmgkbrs34594498
gwascentralrs34594498
openSNPrs34594498
23andMers34594498
SNPshotrs34594498
SNPdbers34594498
MSV3drs34594498
GWAS Ctlgrs34594498
GMAF0.003214
Max Magnitude2.5

rs34594498, also known as c.1256C>T, p.Ala419Val and A419V, represents a variant in the LRRK2 gene on chromosome 12.

The minor allele of this variant has been reported in some studies - and not others - to increase risk (by about 2x) for Parkinson's disease, primarily in studies of Asians. Some of the studies confirming or refuting this variant's role include:

Reporting an association:

  • [PMID 26234753] 2015 study reports a ~2x higher risk for PD in Chinese patients and based on meta-analysis;
  • [PMID 21885347OA-icon.png] 2011 study reports a ~2x higher risk for PD in Asian patients (but not Caucasians)


Finding no association:

  • [PMID 23771111OA-icon.png] 2013 study of ~400 Chinese, Malays and Indians finds no association
  • [PMID 23182315] 2012 study of ~600 Taiwenese PD patients reported no association
  • [PMID 22807999OA-icon.png] 2012 study of ~1,500 Chinese PD patients reported no association


ClinVar
Risk rs34594498(T;T)
Alt rs34594498(T;T)
Reference Rs34594498(C;C)
Significance Pathogenic
Disease Parkinson disease 8
Variation info
Gene LRRK2
CLNDBN Parkinson disease 8, autosomal dominant
Reversed 0
HGVS NC_000012.11:g.40646786C>T
CLNSRC UniProtKB (protein)
CLNACC RCV000032405.1,



[PMID 16633828] A common missense variant in the LRRK2 gene, Gly2385Arg, associated with Parkinson's disease risk in Taiwan. Note that this 2006 study concluded that Ala419Val was a "disease-unrelated polymorphism".