rs6494223

plus

Geno	Mag	Summary
(C;C)		normal
(C;T)		in ALZ patients, increased risk of delusions
(T;T)		in ALZ patients, increased risk of delusions

Reference

GRCh38 38.1/141

Chromosome

15

Position

32104256

Gene

CHRNA7

is a	snp
is	mentioned by
dbSNP	rs6494223
dbSNP (classic)	rs6494223
ClinGen	rs6494223
ebi	rs6494223
HLI	rs6494223
Exac	rs6494223
Gnomad	rs6494223
Varsome	rs6494223
LitVar	rs6494223
Map	rs6494223
PheGenI	rs6494223
Biobank	rs6494223
1000 genomes	rs6494223
hgdp	rs6494223
ensembl	rs6494223
geneview	rs6494223
scholar	rs6494223
google	rs6494223
pharmgkb	rs6494223
gwascentral	rs6494223
openSNP	rs6494223
23andMe	rs6494223
SNPshot	rs6494223
SNPdbe	rs6494223
MSV3d	rs6494223
GWAS Ctlg	rs6494223

GMAF

0.4578

Max Magnitude

0

?

(C;C) (C;T) (T;T)

28

A significant association between delusions and the rs6494223(T) allele (odds ratio 1.63, CI: 1.22-2.17, p = 0.014, ) was found in a cohort of Alzheimer's disease patients in Northern Ireland.[PMID 18696274]

[PMID 20463630] Evidence for association of the non-duplicated region of CHRNA7 gene with bipolar disorder but not with Schizophrenia

[PMID 21550667] CHRNA7 haplotypes are associated with impaired attention in euthymic bipolar disorder.

[PMID 25054019 ] Meta-analyses of 10 polymorphisms associated with the risk of schizophrenia

[PMID 24951635] Effect of APOE and CHRNA7 genotypes on the cognitive response to cholinesterase inhibitor treatment at different stages of Alzheimer's disease