rs6675281
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | common |
| (C;T) | None | |
| (T;T) | None |
| Reference | GRCh38 38.1/141 |
| Chromosome | 1 |
| Position | 231818355 |
| Gene | DISC1, DISC2, LOC105373170, TSNAX-DISC1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs6675281 |
| dbSNP (classic) | rs6675281 |
| ClinGen | rs6675281 |
| ebi | rs6675281 |
| HLI | rs6675281 |
| Exac | rs6675281 |
| Gnomad | rs6675281 |
| Varsome | rs6675281 |
| LitVar | rs6675281 |
| Map | rs6675281 |
| PheGenI | rs6675281 |
| Biobank | rs6675281 |
| 1000 genomes | rs6675281 |
| hgdp | rs6675281 |
| ensembl | rs6675281 |
| geneview | rs6675281 |
| scholar | rs6675281 |
| rs6675281 | |
| pharmgkb | rs6675281 |
| gwascentral | rs6675281 |
| openSNP | rs6675281 |
| 23andMe | rs6675281 |
| SNPshot | rs6675281 |
| SNPdbe | rs6675281 |
| MSV3d | rs6675281 |
| GWAS Ctlg | rs6675281 |
| GMAF | 0.09275 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
linked to schizophrenia
[PMID 19805229
] DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms
[PMID 20505556] Association of DISC1 gene with schizophrenia in families from two distinct French and Algerian populations
[PMID 15386212] Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder.
[PMID 19255581] Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies.
[PMID 19300510] The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes.
[PMID 19414483] The DISC locus and schizophrenia: evidence from an association study in a central European sample and from a meta-analysis across different European populations.
[PMID 20531374] Association of Disrupted in Schizophrenia 1 (DISC1) missense variants with ultra-resistant schizophrenia.
[PMID 21878470] Effect of DISC1 on the P300 Waveform in Psychosis.
[PMID 23389941] DISC1 in adult ADHD patients: An association study in two European samples
[PMID 23140672] DISC1 (disrupted-in-schizophrenia 1) is associated with cortical grey matter volumes in the human brain: a voxel-based morphometry (VBM) study
| ClinVar | |
|---|---|
| Risk | Rs6675281(T;T) |
| Alt | Rs6675281(T;T) |
| Reference | Rs6675281(C;C) |
| Significance | Untested |
| Disease | not provided |
| Variation | info |
| Gene | DISC2 TSNAX-DISC1 DISC1 |
| CLNDBN | not provided |
| Reversed | 0 |
| HGVS | NC_000001.10:g.231954101C>T |
| CLNSRC | ClinVar |
| CLNACC | RCV000084646.1, |
[PMID 23602339] Human brain imaging studies of DISC1 in schizophrenia, bipolar disorder and depression: a systematic review.
