rs7171755

plus

Geno	Mag	Summary
(A;A)	1.1	very slight descrease in cortical thickness and IQ; see full description
(A;G)	1.1	very slight decrease in cortical thickness and IQ; see full text
(G;G)	1	common/normal

Reference

GRCh38 38.1/141

Chromosome

15

Position

73558239

Gene

REC114

is a	snp
is	mentioned by
dbSNP	rs7171755
dbSNP (classic)	rs7171755
ClinGen	rs7171755
ebi	rs7171755
HLI	rs7171755
Exac	rs7171755
Gnomad	rs7171755
Varsome	rs7171755
LitVar	rs7171755
Map	rs7171755
PheGenI	rs7171755
Biobank	rs7171755
1000 genomes	rs7171755
hgdp	rs7171755
ensembl	rs7171755
geneview	rs7171755
scholar	rs7171755
google	rs7171755
pharmgkb	rs7171755
gwascentral	rs7171755
openSNP	rs7171755
23andMe	rs7171755
SNPshot	rs7171755
SNPdbe	rs7171755
MSV3d	rs7171755
GWAS Ctlg	rs7171755

GMAF

0.4853

Max Magnitude

1.1

?

(A;A) (A;G) (G;G)

28

rs7171755 is a SNP near the synaptic cell adhesion glycoprotein-encoding NPTN gene.

A study of ~1,500 adolescents determined that the rs7171755(A) allele is associated with a slightly thinner left hemisphere cortex and also a slight decrease in verbal and nonverbal intelligence (IQ). The differences were really quite slight; each copy of the risk allele decreased cortical thickness by 0.7%, and decreased verbal and nonverbal IQ by 1.8 and 1.4 points, respectively. This study awaits independent replication. Also, note that eight SNPs in the NPTN locus were reported as jointly showing significant association with cortical thickness in addition to rs7171755: rs7176637, rs11854138, rs8028749, rs12185108, rs1564492, rs899981, rs7178269 and rs4075802.10.1038/mp.2013.197