rs735665

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(G;G)	0	common on affy axiom data

Make rs735665(A;A)

Make rs735665(A;G)

Reference

GRCh38 38.1/141

Chromosome

11

Position

123490689

Gene

GRAMD1B

is a	snp
is	mentioned by
dbSNP	rs735665
dbSNP (classic)	rs735665
ClinGen	rs735665
ebi	rs735665
HLI	rs735665
Exac	rs735665
Gnomad	rs735665
Varsome	rs735665
LitVar	rs735665
Map	rs735665
PheGenI	rs735665
Biobank	rs735665
1000 genomes	rs735665
hgdp	rs735665
ensembl	rs735665
geneview	rs735665
scholar	rs735665
google	rs735665
pharmgkb	rs735665
gwascentral	rs735665
openSNP	rs735665
23andMe	rs735665
SNPshot	rs735665
SNPdbe	rs735665
MSV3d	rs735665
GWAS Ctlg	rs735665

GMAF

0.1074

Max Magnitude

0

?	(A;A) (A;G) (G;G)	28

23andMe blog chronic lymphocytic leukemia

• rs735665 A 1.45

news Slager and colleagues validated these in an independent sample of patients. The strongest association was for rs735665 on 11q24, where the risk was 50 percent higher. This was closely followed by a 39 percent increased risk associated with rs9378805 on 6p25.

GWAS
SNP	rs735665
PubMedID	[PMID 18758461]
Condition	Chronic lymphocytic leukemia
Gene	GRAMD1B
Risk Allele	A
pValue	4.00E-012
OR	1.45
95% CI	1.31-1.61

OMIM	612559
Desc	LEUKEMIA, CHRONIC LYMPHOCYTIC SUSCEPTIBILITY TO, 5
Variant
Related	also

[PMID 20332261] Genetic Susceptibility Variants for Chronic Lymphocytic Leukemia

GWAS snp
PMID	[PMID 20639881]
Trait	Follicular lymphoma
Title	Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32
Risk Allele	T
P-val	4E-9
Odds Ratio	1.81 [1.50-2.20]

[PMID 20855867] Inherited genetic susceptibility to monoclonal B-cell lymphocytosis

[PMID 19620980] Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma.

[PMID 20731705] Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong.

GWAS snp
PMID	[PMID 22700719]
Trait
Title	Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia.
Risk Allele	A
P-val	3E-12
Odds Ratio	1.5200 None

GWAS snp
PMID	[PMID 23770605]
Trait	Chronic lymphocytic leukemia
Title	Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
Risk Allele	A
P-val	4E-39
Odds Ratio	1.62 [NR]

[PMID 23455380] Risk of genome-wide association study-identified genetic variants for non-Hodgkin lymphoma in a Chinese population.

GWAS snp
PMID	[PMID 24292274]
Trait	Chronic lymphocytic leukemia
Title	A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
Risk Allele	A
P-val	4E-24
Odds Ratio	1.64 [NR]

[PMID 29547969] A genome-wide association study of IgM antibody against phosphorylcholine: shared genetics and phenotypic relation to chronic lymphocytic leukemia.