rs7539542
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0.51x decreased breast cancer risk | |
| (C;G) | 0.59x decreased breast cancer risk | |
| (G;G) | normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 1 |
| Position | 202940846 |
| Gene | ADIPOR1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs7539542 |
| dbSNP (classic) | rs7539542 |
| ClinGen | rs7539542 |
| ebi | rs7539542 |
| HLI | rs7539542 |
| Exac | rs7539542 |
| Gnomad | rs7539542 |
| Varsome | rs7539542 |
| LitVar | rs7539542 |
| Map | rs7539542 |
| PheGenI | rs7539542 |
| Biobank | rs7539542 |
| 1000 genomes | rs7539542 |
| hgdp | rs7539542 |
| ensembl | rs7539542 |
| geneview | rs7539542 |
| scholar | rs7539542 |
| rs7539542 | |
| pharmgkb | rs7539542 |
| gwascentral | rs7539542 |
| openSNP | rs7539542 |
| 23andMe | rs7539542 |
| SNPshot | rs7539542 |
| SNPdbe | rs7539542 |
| MSV3d | rs7539542 |
| GWAS Ctlg | rs7539542 |
| GMAF | 0.4986 |
| Max Magnitude | 0 |
| ? | (C;C) (C;G) (G;G) | 28 |
|---|---|---|
|
| ||
A study of 733 breast cancer cases for 10 SNPs concluded that a rs7539542 genotype was associated with decreased risk (odds ratio 0.51, CI: 0.28-0.92).[PMID 18451143
]
After categorizing individuals by adiponectin signaling status, this study found that compared with high signalers, intermediate signalers had a 4.16-fold increase in breast cancer risk (CI: 0.49-35.19), and low signalers had a 6.56x higher breast cancer risk (CI: 0.78-54.89, p(trend) = 0.001).[PMID 18451143]
Adiponectin signaling status was assigned as follows:
rs1501299(G,G) + rs2241766(T,T) = low signaler
rs1501299(G,T) + rs2241766(T,T) = low signaler
rs1501299(G,G) + rs2241766(G,T) = low signaler
rs1501299(T,T) + rs2241766(T,T) = intermediate signaler
rs1501299(G,T) + rs2241766(G,T) = intermediate signaler
rs1501299(G,G) + rs2241766(G,G) = intermediate signaler
rs1501299(G,T) + rs2241766(G,G) = high signaler
rs1501299(T,T) + rs2241766(G,G) = high signaler
rs1501299(T,T) + rs2241766(G,T) = high signaler
[PMID 21397927] Polymorphisms of ADIPOQ and ADIPOR1 and prostate cancer risk
[PMID 16724230] Association of sequence variations in the gene encoding adiponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish Diabetes Prevention Study.
[PMID 16955209] Association between variants in the genes for adiponectin and its receptors with insulin resistance syndrome (IRS)-related phenotypes in Mexican Americans.
[PMID 17216283] Adiponectin receptor genes: mutation screening in syndromes of insulin resistance and association studies for type 2 diabetes and metabolic traits in UK populations.
[PMID 18827209] Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk.
[PMID 19037660] The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents.
[PMID 27899942] Adiponectin receptor 1 and small ubiquitin-like modifier 4 polymorphisms are associated with risk of coronary artery disease without diabetes.
