rs795484

Linked to morphine dose and postoperative pain in tonsillectomy and adenoidectomy

Orientation

minus

Stabilized

minus

Geno	Mag	Summary
(A;A)	2.5	Even more increased morphine dose requirement and postoperative pain in tonsillectomy and adenoidectomy
(A;G)	2.1	Increased morphine dose requirement and postoperative pain in tonsillectomy and adenoidectomy
(G;G)	1.1	Normal morphine dose requirement and postoperative pain in tonsillectomy and adenoidectomy

Reference

GRCh38 38.1/142

Chromosome

12

Position

118152057

Gene

TAOK3

is a	snp
is	mentioned by
dbSNP	rs795484
dbSNP (classic)	rs795484
ClinGen	rs795484
ebi	rs795484
HLI	rs795484
Exac	rs795484
Gnomad	rs795484
Varsome	rs795484
LitVar	rs795484
Map	rs795484
PheGenI	rs795484
Biobank	rs795484
1000 genomes	rs795484
hgdp	rs795484
ensembl	rs795484
geneview	rs795484
scholar	rs795484
google	rs795484
pharmgkb	rs795484
gwascentral	rs795484
openSNP	rs795484
23andMe	rs795484
SNPshot	rs795484
SNPdbe	rs795484
MSV3d	rs795484
GWAS Ctlg	rs795484

Max Magnitude

2.5

?	(A;A) (A;G) (G;G)	28

GWAS snp
PMID	[PMID 24909733]
Trait	Morphine dose requirement in tonsillectomy and adenoidectomy surgery
Title	TAOK3, a novel genome-wide association study locus associated with morphine requirement and postoperative pain in a retrospective pediatric day surgery population.
Risk Allele	A
P-val	3E-7
Odds Ratio	16.10 [10.0-21.1] unit increase

Each minor allele at rs795484 (guanine [G]>adenine [A]) contributed +17.6 μg/kg (95% confidence interval [CI] 10.7-24.4) to dose. Effect direction and magnitude were replicated in an independent cohort of 75 EC children (P<0.05). No association with morphine dose was detected in African Americans (AA) (n=241). Postoperative pain scores ≥ 7/10 were associated with rs795484 (G>A) in the EC cohort (odds ratio 2.35, 95% CI 1.56-3.52, P<0.00005) and this association replicated in AA children (odds ratio 1.76, 95% CI 1.14-2.71, P<0.01).

[PMID 24909733]