|(A;A)||0||~18% more likely to respond to citalopram|
|(G;G)||~18% less likely to respond to citalopram|
From this article [PMID 16642436]:
"HTR2A encodes the serotonin 2A receptor, which is downregulated by citalopram. Participants who were homozygous for the A allele had an 18% reduction in absolute risk of having no response to treatment, compared with those homozygous for the other allele."
- See also Anxiety Blog posting
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[PMID 18803430] Pharmacogenetics of major depression: insights from level 1 of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial.
[PMID 19077664] Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response.
[PMID 19381154] Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene-environment study.
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[PMID 20194481] Association of mu-opioid receptor variants and response to citalopram treatment in major depressive disorder.
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[PMID 21741447] Interaction between two HTR2A polymorphisms and gender is associated with treatment response in MDD.
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[PMID 23733030] Pharmacogenetics in major depression: a comprehensive meta-analysis.
[PMID 26544898] The impact of serotonin receptor 1A and 2A gene polymorphisms and interactions on suicide attempt and suicide risk in depressed patients with insufficient response to treatment - a European multicentre study
|Disease||Selective serotonin reuptake inhibitors response - Efficacy antidepressants response - Efficacy citalopram response - Efficacy|
|CLNDBN||Selective serotonin reuptake inhibitors response - Efficacy antidepressants response - Efficacy citalopram response - Efficacy|
|CLNSRC||PharmGKB Clinical Annotation|
|CLNACC||RCV000211197.1, RCV000211254.1, RCV000211379.1,|