| Geno
|
Mag
|
Summary
|
| (G;G)
|
|
slightly increased heart attack risk
|
| (G;T)
|
|
slightly increased heart attack risk
|
| (T;T)
|
0
|
normal risk
|
rs8089, a SNP in the thrombospondin-2 THBS2 gene, was studied as part of a large study (>5,000 Caucasian patients) for risk of myocardial infarction and thus heart disease. Although statistically not overwhelming, a risk was seen (odds ratio 1.19, CI: 1.02-1.39, compared to (T;T) homozygotes) for carriers of the less common rs8089(G) allele. In a meta-analysis combining several studies, no statistically significant association for heart attacks was seen for rs8089, nor for that matter, 2 other SNPs, rs2228262 (also known as Asn700Ser) or rs1866389 (also known as Ala387Pro), in thrombospondins -1 and -4, respectively.[PMID 18178577]
[PMID 18455130
] A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation.
[PMID 21762961] An association study of thrombospondin 1 and 2 SNPs with coronary artery disease and myocardial infarction among South Indians.
[PMID 25664109] Impact of thrombospondin-2 gene variations on the risk of thoracic aortic dissection in a Chinese Han population
] A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation.
