rs925489
Orientation | plus |
Stabilized | plus |
Make rs925489(C;C) |
Make rs925489(C;T) |
Make rs925489(T;T) |
Reference | GRCh38 38.1/141 |
Chromosome | 9 |
Position | 97784318 |
is a | snp |
is | mentioned by |
dbSNP | rs925489 |
dbSNP (classic) | rs925489 |
ClinGen | rs925489 |
ebi | rs925489 |
HLI | rs925489 |
Exac | rs925489 |
Gnomad | rs925489 |
Varsome | rs925489 |
LitVar | rs925489 |
Map | rs925489 |
PheGenI | rs925489 |
Biobank | rs925489 |
1000 genomes | rs925489 |
hgdp | rs925489 |
ensembl | rs925489 |
geneview | rs925489 |
scholar | rs925489 |
rs925489 | |
pharmgkb | rs925489 |
gwascentral | rs925489 |
openSNP | rs925489 |
23andMe | rs925489 |
SNPshot | rs925489 |
SNPdbe | rs925489 |
MSV3d | rs925489 |
GWAS Ctlg | rs925489 |
GMAF | 0.2254 |
Max Magnitude | 0 |
? | (C;C) (C;T) (T;T) | 28 |
---|---|---|
|
Highest association to hypothyroidism in 23andMe cohort based [PMID 22493691], association found also in the first hypothyroidism GWAS [PMID 21981779]. It is 69kb upstream of the gene FOXE1 Forkhead Box E1 which is also known as TTF-2 Thyroid Transcription Factor 2, whose expression it affects according to the first study. In the more recent study, it had an odds ratio of 0.78 with a p-value of 2.4*10-19, meaning the minor allele C is protective. In the first study the C allele was also found associated with lower Serum thyroid-stimulating hormone levels, and homozygous CC allele potentially associated with Papillary Thyroid Cancer.
[PMID 24852370] Genome-wide association study identifies a novel susceptibility gene for serum TSH levels in Chinese populations.
[PMID 22493691] Novel associations for hypothyroidism include known autoimmune risk Loci
[PMID 21981779] Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies.
GWAS snp | |
---|---|
PMID | [PMID 24852370] |
Trait | Serum thyroid-stimulating hormone levels |
Title | Genome-wide association study identifies a novel susceptibility gene for serum TSH levels in Chinese populations. |
Risk Allele | C |
P-val | 1E-13 |
Odds Ratio | .06 [NR] unit decrease |