| Geno
|
Mag
|
Summary
|
| (C;C)
|
0
|
common/normal
|
| (C;T)
|
1.7
|
slightly increased risk for multiple sclerosis in females
|
| (T;T)
|
2
|
slightly increased risk for multiple sclerosis in females
|
rs9282860 is a SNP within intron 5 of the STK11 gene; the minor allele is carried by about 7% of the population in one study.
Based on sequencing of a family in which five siblings were diagnosed with multiple sclerosis (MS), rs9282860 was then screened in 654 relapsing-remitting MS patients, 100 primary progressive MS patients, and 661 controls. rs9282860(T) was found more frequently in all female patients versus controls (odds ratio 1.66, CI: 1.05-2.64, p = .032). However, it was not associated with disease duration or onset. It was significantly associated with reduced severity, with the lowest MS severity scores in patients who also harbored the HLA-DRB1*1501 allele (tagged by rs3135388 and by itself strongly associated with MS).[PMID 25694554
]
]
