SLCO1B1
From SNPedia
| is a | gene |
| is | mentioned by |
| Full name | solute carrier organic anion transporter family, member 1B1 |
| EntrezGene | 10599 |
| PheGenI | 10599 |
| VariationViewer | 10599 |
| ClinVar | SLCO1B1 |
| GeneCards | SLCO1B1 |
| dbSNP | 10599 |
| Diseases | SLCO1B1 |
| SADR | 10599 |
| HugeNav | 10599 |
| wikipedia | SLCO1B1 |
| SLCO1B1 | |
| gopubmed | SLCO1B1 |
| EVS | SLCO1B1 |
| HEFalMp | SLCO1B1 |
| MyGene2 | SLCO1B1 |
| 23andMe | SLCO1B1 |
| UniProt | Q9Y6L6 |
| Ensembl | ENSG00000134538 |
| OMIM | 604843 |
| # SNPs | 30 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| rs10841753 | 0 | 21,168,436 | |
| rs11045818 | 0 | 21,176,827 | |
| rs11045819 | 0 | 21,176,879 | |
| rs11045849 | 0 | 21,196,677 | |
| rs11045879 | 0 | 21,229,685 | |
| rs12317268 | 0 | 21,199,607 | |
| rs12582717 | 0 | 21,143,872 | |
| rs12829704 | 0 | 21,235,687 | |
| rs1564370 | 0 | 21,182,256 | |
| rs183501729 | 0 | 21,196,975 | |
| rs1871395 | 0 | 21,199,381 | |
| rs2291075 | 0 | 21,178,691 | |
| rs2306283 | 0 | 21,176,804 | |
| rs4149013 | 0 | 21,129,476 | |
| rs4149014 | 0 | 21,130,019 | |
| rs4149015 | 0 | 21,130,388 | |
| rs4149018 | 0 | 21,138,627 | |
| rs4149056 | 3.2 | 21,178,615 | Influences statin response |
| rs4149080 | 0 | 21,224,625 | |
| rs4149081 | 0 | 21,225,087 | |
| rs4149086 | 0 | 21,239,517 | |
| rs4363657 | 4 | 21,215,788 | |
| rs55737008 | 0 | 21,239,113 | |
| rs55901008 | 0 | 21,200,595 | |
| rs56061388 | 0 | 21,174,595 | |
| rs56101265 | 0 | 21,172,782 | |
| rs59502379 | 0 | 21,205,999 | |
| rs71581941 | 0 | 21,222,355 | |
| rs72559745 | 0 | 21,176,883 | |
| rs7489119 | 0 | 21,152,364 |
SLCO1B1, is a protein organic anion transporter, specific to the liver, that mediates uptake of numerous compounds and is involved in removing drugs from the blood into the liver. Variants have been connected to neonatal hyperbilirubinemia and statin response.
rs4149056, 37041T>C, the SLCO1B1*5 allele, has reduced activity, leading to higher drug concentrations and worse outcomes with statins.
Different alleles influence statin response:
- rs72559745 (SLCO1B1*1)
- rs56061388 (SLCO1B1*3)
- rs4149056 (SLCO1B1*5)
- rs55901008 (SLCO1B1*6)
