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ORMDL3

From SNPedia

is agene
is mentioned by
Full nameORM1-like 3 (S. cerevisiae)
EntrezGene94103
PheGenI94103
VariationViewer94103
ClinVarORMDL3
GeneCardsORMDL3
dbSNP94103
SADR94103
HugeNav94103
wikipediaORMDL3
googleORMDL3
gopubmedORMDL3
EVSORMDL3
HEFalMpORMDL3
MyGene2ORMDL3
23andMeORMDL3
UniProtQ8N138
EnsemblENSG00000172057
OMIM610075
# SNPs7
 Max MagnitudeChromosome positionSummary
rs1260333239,926,554
rs1760892539,926,578
rs3169572039,921,159
rs374424639,928,097
rs406527539,924,612
rs437865039,924,612
rs807613139,924,659

The ORMDL3 gene on chromosome 17q21 has been associated with asthma in several studies. SNPs either in or near enough to influence ORMDL3 include:

[PMID 18923164] and NEJM conclude the following: "This study shows that the increased risk of asthma conferred by 17q21 genetic variants is restricted to early-onset asthma and that the risk is further increased by early-life exposure to environmental tobacco smoke." {Note: early-onset refers to the onset of asthma at the age of 4 years or younger.} The ch 17q21 SNPs mentioned in this article are:

These authors are uncertain of the role played by the ORMDL3 gene, and mention 3 other genes also in the 17q21 region which might be involved instead of (or in addition to) ORMDL2: ZPBP2, IKZF3, and GSDML.