|(C;T)||complex; see details|
|(T;T)||complex; see details|
|On GW 5.0||0|
|Odds Ratio Het||1.89|
|Odds Ratio Hom||1.59|
|Odds Ratio All||1.50|
|Disease||Ulcerative colitis (UC)|
rs1143634, also known as +3954, is a SNP in the IL-1 beta IL1B gene.
A study of 556 adults in the Western Australian coronary heart disease (CHD) population concluded that rs1143634(T;T) homozygotes had larger waist circumference, by 1.8cm on average, compared to major allele (C;C) homozygotes. This association was even more pronounced in patients with higher levels of obesity or inflammatory markers.[[https://www.ncbi.nlm.nih.gov/pubmed/ 18716798?dopt=Abstract PMID 18716798]]
rs1143634 increases susceptibility to Alzheimer's disease 2.33 times for homozygotes (TT) [PMID 10976648]
rs1143634 increases susceptibility to Cervical lesions, low-grade squamous intraepithelial lesions 4.29 times for heterozygotes (CT) and 3.57 times for homozygotes (TT) [PMID 10366460]
rs1143634 increases susceptibility to Duodenal ulcer 1.14 times for carriers of the T allele [PMID 11531943]
rs1143634 increases susceptibility to Inflammatory bowel disease 7.32 times for carriers of the T allele [PMID 11220627]
rs1143634 increases susceptibility to Joint destruction in Rheumatoid Arthritis 1.70 times for carriers of the T allele [PMID 11477478]
rs1143634 increases susceptibility to Myasthenia gravis 1.29 times for heterozygotes (CT) and 4.63 times for homozygotes (TT) [PMID 9521608]
rs1143634 increases susceptibility to Nephropathy in Type I Diabetes 2.03 times for heterozygotes (CT) and 5.01 times for homozygotes (TT) [PMID 10049523]
rs1143634 increases susceptibility to Peptic ulcer disease 1.06 times for carriers of the T allele [PMID 11531943]
rs1143634 increases susceptibility to Periodontitis 2.85 times for heterozygotes (CT) and 4.89 times for homozygotes (TT) [PMID 10589805]
rs1143634 increases susceptibility to Periodontitis 3.33 times for carriers of the T allele [PMID 9797049]
rs1143634 increases susceptibility to Survival in pancreatic cancer for carriers of the T allele [PMID 11076651]
rs1143634 increases susceptibility to Ulcerative colitis 1.89 times for heterozygotes (CT) and 1.59 times for homozygotes (TT) [PMID 9771403]
[PMID 19684156] Association Between Interleukin 1 Gene Cluster Polymorphisms and Bilateral Distal Interphalangeal Osteoarthritis
[PMID 20031567] An Evaluation of Candidate Genes of Inflammation and Thrombosis in Relation to the Risk of Venous Thromboembolism: The Women's Genome Health Study
[PMID 20035239] IL1B rs1143634 Polymorphism, Cigarette Smoking, Alcohol Use, and Lung Cancer Risk in a Japanese Population
[PMID 19820020] Association of variation in the interleukin-1 gene family with diabetes and glucose homeostasis
[PMID 20565898] Association of IL1A and IL1B loci with primary open angle glaucoma
[PMID 20671275] Association of Interleukin-1 beta (IL1B) polymorphisms with Grave's Ophthalmopathy in Taiwan Chinese patients
[PMID 21726461] Modulation of cortisol responses to the DEX/CRH test by polymorphisms of the interleukin-1beta gene in healthy adults
[PMID 21843369] Possible association between Interleukin-1beta gene and schizophrenia in a Japanese population
[PMID 21672595] Single nucleotide polymorphisms in interleukin-1gene cluster and subgingival colonization with Aggregatibacter actinomycetemcomitans in patients with aggressive periodontitis
[PMID 21968104] The association of genetic variants in interleukin-1 genes with cognition: findings from the cardiovascular health study
[PMID 22285486] Association of IL1R polymorphism with HLA-B27 positive in Iranian patients with ankylosing spondylitis
[PMID 22227487] Polymorphisms in inflammasome' genes and susceptibility to HIV-1 infection.
[PMID 22788685] Polymorphisms of pro-inflammatory cytokine genes and the risk for acute suppurative or chronic nonsuppurative apical periodontitis in a Colombian population
[PMID 15726497] Gene-environment interaction effects on the development of immune responses in the 1st year of life.
[PMID 16508980] Association of the IL1 gene cluster with susceptibility to ankylosing spondylitis: an analysis of three Canadian populations.
[PMID 16820586] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.
[PMID 16842617] Interleukin gene polymorphisms and breast cancer: a case control study and systematic literature review.
[PMID 17327408] Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.
[PMID 17532232] Potential influence of IL1B haplotype and IL1A-IL1B-IL1RN extended haplotype on hand osteoarthritis risk.
[PMID 17601350] A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
[PMID 17665434] Association of interleukin-6 and interleukin-10 genotypes with radiographic damage in rheumatoid arthritis is dependent on autoantibody status.
[PMID 18216863] Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families.
[PMID 18500540] Fine-mapping the genetic basis of CRP regulation in African Americans: a Bayesian approach.
[PMID 18573495] IL1B genetic variation and plasma C-reactive protein level among young adults: the CARDIA study.
[PMID 18576312] A broad analysis of IL1 polymorphism and rheumatoid arthritis.
[PMID 18603647] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.
[PMID 18633131] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.
[PMID 18676870] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.
[PMID 18715339] Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population.
[PMID 18715757] Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.
[PMID 18757527] Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer.
[PMID 18805939] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.
[PMID 18813964] Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta.
[PMID 18830724] Assessment of Alzheimer's disease case-control associations using family-based methods.
[PMID 18842150] Concurrent genotyping of Helicobacter pylori virulence genes and human cytokine SNP sites using whole genome amplified DNA derived from minute amounts of gastric biopsy specimen DNA.
[PMID 19035492] Cytokine gene polymorphisms as risk and severity factors for juvenile dermatomyositis.
[PMID 19043479] Association of -31T>C and -511 C>T polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients.
[PMID 19066394] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.
[PMID 19092239] Common variants in interleukin-1-Beta gene are associated with intracranial hemorrhage and susceptibility to brain arteriovenous malformation.
[PMID 19131662] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
[PMID 19263529] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
[PMID 19330901] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
[PMID 19356949] Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.
[PMID 19468064] Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.
[PMID 19478423] Cytokine response to vitamin E supplementation is dependent on pre-supplementation cytokine levels.
[PMID 19559392] A candidate gene association study of 77 polymorphisms in migraine.
[PMID 19619703] Association of genetic variants with the metabolic syndrome in 20,806 white women: The Women's Health Genome Study.
[PMID 19729864] Association of genetic variation in serum amyloid-A with cardiovascular disease and interactions with IL6, IL1RN, IL1beta and TNF genes in the Cardiovascular Health Study.
[PMID 19911060] Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.
[PMID 19934104] Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations.
[PMID 20044070] The interleukin 1 beta (IL1B) gene is associated with failure to achieve remission and impaired emotion processing in major depression.
[PMID 20113413] Cytokine polymorphism in patients with migraine: some suggestive clues of migraine and inflammation.
[PMID 20175886] Variable number of tandem repeat polymorphisms of the interleukin-1 receptor antagonist gene IL-1RN: a novel association with the athlete status.
[PMID 20192980] The interleukin-1 cluster gene region is associated with multiple sclerosis in an Italian Caucasian population.
[PMID 20196868] Polymorphisms in IL-1beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis.
[PMID 20347268] Convergent evidence shows a positive association of interleukin-1 gene complex locus with susceptibility to schizophrenia in the Caucasian population.
[PMID 20353565] Allelic variants of IL1R1 gene associate with severe hand osteoarthritis.
[PMID 20437198] Three polymorphisms in interleukin-1beta gene and risk for breast cancer: a meta-analysis.
[PMID 20463618] Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.
[PMID 20574532] Intermediate phenotypes identify divergent pathways to Alzheimer's disease.
[PMID 20811626] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.
[PMID 21146623] Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis.
[PMID 21172166] Pharmacogenetics of antidepressant response.
[PMID 21205020] Associations between interleukin-1 (IL-1) gene variations or IL-1 receptor antagonist levels and the development of type 2 diabetes.
[PMID 21279638] Coding single-nucleotide polymorphisms of interleukin-1 gene cluster are not associated with Kawasaki disease in the Korean population.
[PMID 22035161] Postorthodontic external root resorption is associated with IL1 receptor antagonist gene variations.
[PMID 22341060] Postorthodontic external root resorption in root-filled teeth is influenced by interleukin-1beta polymorphism.
[PMID 23049925] IL1 Receptor Antagonist Gene IL1-RN Variable Number of Tandem Repeats Polymorphism and Cancer Risk: A Literature Review and Meta-Analysis
|qualified_impact||Insufficiently evaluated pharmacogenetic|
[PMID 23192617] IL-1RN +2018T>C polymorphism is correlated with colorectal cancer
[PMID 23216199] Associations of the interleukin-1 gene locus polymorphisms with risk to hip and knee osteoarthritis: gender and subpopulation differences
[PMID 23713812] Assessment of Interleukin-1 Gene Cluster Polymorphisms in Lone Atrial Fibrillation: New Insight into the Role of Inflammation in Atrial Fibrillation
[PMID 24072654] Influence of interleukin gene polymorphisms on development of acute pancreatitis: a systematic review and meta-analysis
[PMID 24460370] Relationship Between IL1 Gene Polymorphisms and Periodontal Disease in Japanese Women
[PMID 24477584] Genetic association of IDE, POU2F1, PON1, IL1α and IL1β with type 2 diabetes in Pakistani population
[PMID 22623017] Serotonin transporter-linked polymorphic region (5-HTTLPR) genotype is associated with cortisol responsivity to naloxone challenge.
[PMID 22818022] Polymorphic variations in IL-1beta, IL-6 and IL-10 genes, their circulating serum levels and breast cancer risk in Indian women.
[PMID 22925444] Genetic and immunological markers predict titanium implant failure: a retrospective study.
[PMID 22960943] Influence of polymorphisms and TNF and IL1beta serum concentration on the infliximab response in Crohn's disease and ulcerative colitis.
[PMID 23029430] Prognostic role of host cyclooxygenase and cytokine genotypes in a Caucasian cohort of patients with gastric adenocarcinoma.
[PMID 23459936] Exploring the genetic basis of chronic periodontitis: a genome-wide association study.
[PMID 23460603] Polymorphisms of Interleukin-1 Beta and Interleukin-17Alpha Genes Are Associated With Restless Legs Syndrome.
[PMID 23722873] Interleukin-1 gene cluster and IL-1 receptor polymorphisms in Iranian patients with systemic lupus erythematosus.
[PMID 25758360] Saving more teeth-a case for personalized care
[PMID 25865535] Genetic and treatment-related risk factors associated with external apical root resorption (EARR) concurrent with orthodontia
[PMID 26391153] Polymorphisms in host immune response associated genes and risk of nasopharyngeal carcinoma development in Portugal
[PMID 26854620] Determination of NLRP3 (rs4612666) and IL-1B (rs1143634) genetic polymorphisms in periodontally diseased and healthy subjects.
[PMID 27602547] Impact of IL1B gene polymorphisms and interleukin 1B levels on susceptibility to spontaneous preterm birth.