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rs16973225

From SNPedia

Stabilizedplus
Geno Mag Summary
(A;A) 2 common/normal; aspirin use reduces colorectal cancer risk a bit
(A;C) 1.5 no reduction in colorectal cancer risk from taking aspirin
(C;C) 1.5 no reduction in colorectal cancer risk from taking aspirin
is asnp
is mentioned by
dbSNPrs16973225
ebirs16973225
HLIrs16973225
Exacrs16973225
Varsomers16973225
Maprs16973225
PheGenIrs16973225
hapmaprs16973225
1000 genomesrs16973225
hgdprs16973225
ensemblrs16973225
gopubmedrs16973225
geneviewrs16973225
scholarrs16973225
googlers16973225
pharmgkbrs16973225
gwascentralrs16973225
openSNPrs16973225
23andMers16973225
23andMe allrs16973225
SNP Nexus

SNPshotrs16973225
SNPdbers16973225
MSV3drs16973225
GWAS Ctlgrs16973225
Max Magnitude2
? (A;A) (A;C) (C;C) 28
rs16973225 is a SNP on chromosome 15q25.2 near the IL16 gene.

In a long-term study of ~17,000 individuals and aspirin or NSAID use, the few (9%) with either an (A;C) or (C;C) genotype showed no risk reduction for colorectal cancer compared with (A;A) individuals among those taking anti-inflammatory drugs, who did benefit (prevalence, 28% vs 38%; (A;A) odds ratio 0.66 when taking aspirin/NSAID, CI: 0.62-0.71, p = 1.9 × 10e−30). 10.1001/jama.2015.1815

If this data is robust and all other factors are equal, this indicates that most people will lower their colorectal cancer risk by taking aspirin or NSAIDs, since most people have rs16973225(A;A) genotypes. However, the few people who are rs16973225(A;C) or are rs16973225(C;C) will not change their risk one way or the other by taking aspirin.

This same study reached somewhat similar conclusions about two other SNPs, rs10505806 and rs2965667.10.1001/jama.2015.1815

[PMID 25781442] Association of Aspirin and NSAID Use With Risk of Colorectal Cancer According to Genetic Variants