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rs2229765

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2.1 Lower IGF-1 levels; some reported associations with longevity as well as certain cancers
(G;G) 1.1 Normal IGF-1 level
Make rs2229765(A;G)
ReferenceGRCh38 38.1/141
Chromosome15
Position98934996
GeneIGF1R
is asnp
is mentioned by
dbSNPrs2229765
ebirs2229765
HLIrs2229765
Exacrs2229765
Varsomers2229765
Maprs2229765
PheGenIrs2229765
hapmaprs2229765
1000 genomesrs2229765
hgdprs2229765
ensemblrs2229765
gopubmedrs2229765
geneviewrs2229765
scholarrs2229765
googlers2229765
pharmgkbrs2229765
gwascentralrs2229765
openSNPrs2229765
23andMers2229765
23andMe allrs2229765
SNP Nexus

SNPshotrs2229765
SNPdbers2229765
MSV3drs2229765
GWAS Ctlgrs2229765
GMAF0.371
Max Magnitude2.1
? (A;A) (A;G) (G;G) 28

[PMID 18477064] rs2229765(A;A) associated with ischemic stroke (OR = 1.641, P = 0.022) in a Chinese population


[PMID 19460140OA-icon.png] A polymorphic variant of the insulin-like growth factor 1 (IGF-1) receptor correlates with male longevity in the Italian population: a genetic study and evaluation of circulating IGF-1 from the "Treviso Longeva (TRELONG)" study


[PMID 22115178] Insulin-like growth factor 1 receptor polymorphism rs2229765 and circulating interleukin-6 level affect male longevity in a population-based prospective study (Treviso Longeva- TRELONG)


[PMID 19124506OA-icon.png] Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.


[PMID 19124510OA-icon.png] Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma.


[PMID 19877134OA-icon.png] Sequence variation in IGF1R is associated with differences in insulin levels in nondiabetic Old Order Amish.


[PMID 20302654OA-icon.png] Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density.


[PMID 20625407OA-icon.png] A comprehensive in silico analysis of the functional and structural impact of SNPs in the IGF1R gene.


[PMID 21047277] Polymorphisms of insulin-like growth factor-1 (IGF-1) and IGF-1 receptor (IGF-1R) contribute to pathologic progression in childhood IgA nephropathy.


[PMID 21304894OA-icon.png] Mapping a new spontaneous preterm birth susceptibility gene, IGF1R, using linkage, haplotype sharing, and association analysis.


[PMID 24350933] Association Between Genetic Variations In The Insulin/Insulin-Like Growth Factor (Igf-1) Signaling Pathway And Longevity: A Systematic Review And Meta-Analysis


[PMID 22909219] Polymorphism of IGF1R is associated with papillary thyroid carcinoma in a Korean population.


[PMID 25189651] Association of insulin-like growth factor-I receptor polymorphism with colorectal cancer development


[PMID 26535220OA-icon.png] Association between exonic polymorphism (rs629849, Gly1619Arg) of IGF2R gene and obesity in Korean population


ClinVar
Risk rs2229765(A;A)
Alt rs2229765(A;A)
Reference rs2229765(G;G)
Significance Non-pathogenic
Disease not specified
Variation info
Gene IGF1R
CLNDBN not specified
Reversed 0
HGVS NC_000015.9:g.99478225G>A
CLNSRC
CLNACC RCV000175020.1,