This SNP is in a linkage block in the FTO gene with rs1121980; see rs1121980 for the association of this block with early onset obesity since it showed the strongest association.[PMID 18159244
]
| GWAS snp
|
| PMID
|
[PMID 22399527]
|
| Trait
|
|
| Title
|
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
|
| Risk Allele
|
A
|
| P-val
|
2E-9
|
| Odds Ratio
|
0.0900 None
|
[PMID 18379722] Variations in the FTO gene are associated with severe obesity in the Japanese.
[PMID 18599522] FTO variants are associated with obesity in the Chinese and Malay populations in Singapore.
[PMID 20017965] Identifying association under a previous linkage peak on chromosome 16 for body mass index using cross-sectional and longitudinal data of the Framingham Heart Study.
[PMID 21175269] Genetic variations in the FTO gene are associated with type 2 diabetes and obesity in south Indians (CURES-79).
| GWAS snp
|
| PMID
|
[PMID 23669352]
|
| Trait
|
Body mass index
|
| Title
|
Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course.
|
| Risk Allele
|
A
|
| P-val
|
4E-23
|
| Odds Ratio
|
.08 [0.067-0.099] unit increase
|
]
