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FTO

From SNPedia

is agene
is mentioned by
Full namefat mass and obesity associated
EntrezGene79068
PheGenI79068
VariationViewer79068
ClinVarFTO
GeneCardsFTO
dbSNP79068
SADR79068
HugeNav79068
wikipediaFTO
googleFTO
gopubmedFTO
EVSFTO
HEFalMpFTO
MyGene2FTO
23andMeFTO
UniProtQ9C0B1
EnsemblENSG00000140718
OMIM610966
# SNPs67
 Max MagnitudeChromosome positionSummary
rs1016340954,104,968
rs1085252153,771,053
rs1107599053,785,981
rs1107599553,821,379
rs1107599653,824,112
rs1107599753,825,000
rs1107600853,893,411
rs110808654,066,457
rs1121980353,775,335
rs1164201553,768,582
rs1164284153,811,575
rs1214983253,808,996
rs121918214053,873,837
rs1259598553,842,839
rs1259621053,994,059
rs1259778653,787,395
rs1292715554,099,888
rs142031854,068,854
rs142108453,723,828
rs14210853.153,767,042obesity risk
rs147719653,774,346
rs155890253,769,662
rs16945088053,778,612
rs169530021.554,080,912
rs1721908453,821,688
rs17817449053,779,455
rs1781796453,794,154
rs1781890253,837,894
rs1782087553,892,878
rs186186853,756,490
rs375181253,784,548
rs382616953,826,569
rs478433353,935,176
rs5613703053,791,993
rs5710384953,844,521
rs6203340053,777,876
rs6204840253,769,311
rs649964053,735,765
rs718573553,788,739
rs719005353,840,745
rs719314453,776,774
rs719553953,825,246
rs720211653,787,703
rs7204609053,799,693
rs804375753,779,538
rs804476953,805,223
rs804739553,764,611
rs80501361.453,782,363
rs805374053,841,800
rs805704453,778,702Associated in African Americans, but not non-Hispanic whites, with adiposity
... further results
  • 2015 research suggests rs1421085 may be the causal variant blog summary
  • Within the FTO gene, rs9930506 showed the strongest association with BMI (p = 8.6 *10-7), hip circumference (p = 3.4 * 10-8) and weight (p = 9.1 * 10-7). homozygotes for the rare "G" allele were 1.3 BMI units heavier than homozygotes for the common "A" allele. More than 30 additional SNPs in or near the FTO gene were also studied, but they are co-inherited most of the time with the rs9930506 SNP and therefore are unlikely to represent independent risk factors. These co-inherited SNPs include rs1421085, rs9937053, rs8043757, rs3751812, rs9923233, rs9932754, and rs9922619. [PMID 17658951]
  • Note: The three FTO SNPs, rs1421085, rs17817449, and rs9939609, are in strong linkage disequilibrium (pairwise r2>0.97), and there are two primary haplotypes, C-G-A (42.0%; this is the haplotype representing obesity risk) and T-T-T (55.5%).
  • Another report fingers rs1121980 within the FTO gene as having the strongest association to early onset obesity compared to several other SNPs all in the same linkage block. [PMID 18159244]

The earlier study also had conclusions with regard to another gene:

  • Within the PFKP gene, rs6602024 showed very strong association with BMI (p = 4.9 * 10-6). Homozygotes for the rare "A" allele of this SNP (minor allele frequency = 0.12) were 1.8 BMI units heavier than homozygotes for the common "G" allele. They did not replicate association between rs6602024 and obesity-related traits in the GenNet sample, although they found that in European Americans, Hispanic Americans and African Americans, homozygotes for the rare "A" allele where, on average, 1.0 - 3.0 BMI units heavier than homozygotes for the more common "G" allele. [PMID 17658951]

New articles about this include:

FTO aka "Fat Gene"[1].

[2] the FTO SNP rs9939609 is associated with changes in BMI and obesity in children by the age of 7 which persists into the pre-pubertal period and beyond.

http://varigenome.blogspot.com/2013/06/fto-and-memory-connecting-dots.html

“Genetic associations with traits in 23andMe customers.” 23andMe White Paper.