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From SNPedia

Aspirin is a generic drug used for many purposes: reducing fever, as an anti-inflammatory, to relieve pain, and as a anti-platelet (anti-clotting) agent. Wikipedia

SNPs may influence how well aspirin works in these roles, as well as the degree to which side effects (primarily gastrointestinal bleeding) are experienced. SNPs reported to be involved with aspirin use include:

  • rs3798220 - with respect to reducing cardiovascular risk
  • rs5918 - with respect to anti-platelet resistance

SNPs may also modify whether aspirin affects the risk for certain disorders. These include:

  • rs6983267 - carriers of one or two (T) alleles for this SNP reduce their colorectal cancer risk if they take aspirin
  • rs10505806, rs16973225 and rs2965667 - carriers of both major alleles at each of these SNPs lower their colorectal cancer risk by taking aspirin or other NSAIDs, but a carrier of one or more minor alleles may either show no benefit or even raise their risk

A 2009 review [PMID 20214591] concluded that the main SNPs influencing aspirin intolerance are:

Regarding aspirin effects, major targets were said to be in the PGTS1 gene; rs3842787 and rs5789 in the gene for European subjects, and rs3842789 and rs3842792 for African subjects.