rs16973225

plus

Geno	Mag	Summary
(A;A)	2	common/normal; aspirin use reduces colorectal cancer risk a bit
(A;C)	1.5	no reduction in colorectal cancer risk from taking aspirin
(C;C)	1.5	no reduction in colorectal cancer risk from taking aspirin

Chromosome

15

Position

81937658

Gene	LOC102724001

is a	snp
is	mentioned by
dbSNP	rs16973225
dbSNP (classic)	rs16973225
ClinGen	rs16973225
ebi	rs16973225
HLI	rs16973225
Exac	rs16973225
Gnomad	rs16973225
Varsome	rs16973225
LitVar	rs16973225
Map	rs16973225
PheGenI	rs16973225
Biobank	rs16973225
1000 genomes	rs16973225
hgdp	rs16973225
ensembl	rs16973225
geneview	rs16973225
scholar	rs16973225
google	rs16973225
pharmgkb	rs16973225
gwascentral	rs16973225
openSNP	rs16973225
23andMe	rs16973225
SNPshot	rs16973225
SNPdbe	rs16973225
MSV3d	rs16973225
GWAS Ctlg	rs16973225

Max Magnitude

2

?

(A;A) (A;C) (C;C)

28

rs16973225 is a SNP on chromosome 15q25.2 near the IL16 gene.

In a long-term study of ~17,000 individuals and aspirin or NSAID use, the few (9%) with either an (A;C) or (C;C) genotype showed no risk reduction for colorectal cancer compared with (A;A) individuals among those taking anti-inflammatory drugs, who did benefit (prevalence, 28% vs 38%; (A;A) odds ratio 0.66 when taking aspirin/NSAID, CI: 0.62-0.71, p = 1.9 × 10e−30). 10.1001/jama.2015.1815

If this data is robust and all other factors are equal, this indicates that most people will lower their colorectal cancer risk by taking aspirin or NSAIDs, since most people have rs16973225(A;A) genotypes. However, the few people who are rs16973225(A;C) or are rs16973225(C;C) will not change their risk one way or the other by taking aspirin.

This same study reached somewhat similar conclusions about two other SNPs, rs10505806 and rs2965667.10.1001/jama.2015.1815

[PMID 25781442 ] Association of Aspirin and NSAID Use With Risk of Colorectal Cancer According to Genetic Variants