| Geno
|
Mag
|
Summary
|
| (A;A)
|
2
|
common/normal; aspirin use reduces colorectal cancer risk a bit
|
| (A;T)
|
2
|
aspirin use may increase colorectal cancer risk a bit
|
| (T;T)
|
2
|
aspirin use may increase colorectal cancer risk a bit
|
rs10505806 is a SNP on chromosome 12.
In a long-term study of ~17,000 individuals and aspirin or NSAID use, the few (5%) with either an (A;T) or (T;T) genotype were almost twice as likely to be diagnosed with colorectal cancer compared with (A;A) individuals among those taking anti-inflammatory drugs ((A;T) and (T;T) odds ratio 1.56 when taking aspirin/NSAID).10.1001/jama.2015.1815
If this data is robust and all other factors are equal, this indicates that most people will lower their colorectal cancer risk by taking aspirin or NSAIDs, since most people have rs10505086(A;A) genotypes. However, the few people who are rs10505806(A;T) or are rs10505806(T;T) should not take aspirin or NSAIDs since doing so may actually raise their colorectal risk.
This same study reached somewhat similar conclusions about two other SNPs, rs2965667 and rs16973225.10.1001/jama.2015.1815
