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From SNPedia
Magnitude 2.6
Repute Bad
Summary Somewhat increased risk of Alzheimer's disease
Criteria Gs327/criteria

You carry a combination of common SNPs in the CLU and MS4A4E genes that appear to interact to moderately increase the risk of Alzheimer's disease (OR=2.45, p=0.0004) compared to what one would expect assuming independence of the individual SNPs (OR=1.20·0.92=1.10) [PMID 26449541OA-icon.png].

This is based on

This is a common combination of these SNPs, with perhaps around 1 in 5 people of most ethnicities sharing this combination.