Gs327
From SNPedia
| Gs327 | |
|---|---|
| Magnitude | 2.6 |
| Repute | Bad |
| Summary | Somewhat increased risk of Alzheimer's disease |
| Criteria | Gs327/criteria |
You carry a combination of common SNPs in the CLU and MS4A4E genes that appear to interact to moderately increase the risk of Alzheimer's disease (OR=2.45, p=0.0004) compared to what one would expect assuming independence of the individual SNPs (OR=1.20·0.92=1.10) [PMID 26449541
].
This is based on
- rs11136000(C;C)
- rs670139(C;C)
This is a common combination of these SNPs, with perhaps around 1 in 5 people of most ethnicities sharing this combination.
