Ovarian cancer

The Wikipedia article on ovarian cancer is a good place to start.

SNPs reported to influence ovarian cancer (OC) often overlap those for breast cancer. At least eleven genes may contain pathogenic mutations for ovarian cancer, including:

• Well-established OC genes (increasing risk >5 fold):
  • BRCA1
  • BRCA2
  • BRIP1
  • RAD51C
  • RAD51D
  • MSH2
  • MLH1
  • PMS2
  • MSH6

• Suspected OC genes (likely to increase risk >2 fold):
  • PALB2
  • BARD1

The following genes may in a more minor way (increasing risk <2 fold) affect relative risk of ovarian cancer:

• HOXD3
  • rs2072590

• SYNE1
  • rs2295190

• RB1
  • rs2227311
  • rs4151620
  • rs2854344

• PGR
  • rs1042838
  • rs608995

• SKAP1
  • rs9303542

• SRD5A2
  • rs523349

• TIPARP
  • rs2665390

• MAGEC3
  • rs176026

As for the good news, some SNPs confer lower risk of ovarian cancer:

• rs3218536 in the DNA repair gene XRCC2
• rs4151620 in the RB1 gene
• rs3814113 in the ch 9p22.2 region
• rs10088218 in the ch 8q24 region