||1.4x increased risk for ovarian cancer
||1.2x increased risk for ovarian cancer
||common in complete genomics
rs2665390 is a SNP in chromosomal region 3q25, in the TCDD-inducible poly(ADP-ribose) polymerase TIPARP gene.
A genome-wide association study ultimately including over 10,000 ovarian cancer patients found statistically strong (p = 7.1 × 10e-8) evidence for slightly elevated risk associated with the rs2665390(C) allele, with an odds ratio of 1.24 (CI: 1.15–1.34) as calculated for the serous subtype (of ovarian cancer).[PMID 20852632]
[PMID 22235027] Evaluation of microRNA expression profiles and their associations with risk alleles in lymphoblastoid cell lines of familial ovarian cancer.
[PMID 22253144] Ovarian cancer susceptibility alleles and risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers.
[PMID 23133607] Associations between gene expression variations and ovarian cancer risk alleles identified from genome wide association studies.
[PMID 25173882] Replication Study for the Association of Seven Genome- Gwas-Identified Loci With Susceptibility to Ovarian Cancer in the Polish Population
[PMID 28505207] Immuno-related polymorphisms and cervical cancer risk: The IARC multicentric case-control study.