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Restless legs syndrome

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(Redirected from Restless leg syndrome)

Restless legs syndrome is a common sleep disorder, and studies implicate a genetic basis and thus an inherited tendency to develop the disorder. SNPs in at least five chromosomal regions, including MEIS1/rs2300478, have been reported to be associated with increased risk for restless legs syndrome. [PMID 17637780, PMID 18660810]

Note: the name for this disorder is in the process of changing to Willis-Ekbom disease.[1]

The chromosomal regions mentioned in connection with restless legs syndrome include:

  • A region on chromosome 12q, most likely involving the NOS1 gene, including SNPs: