rs4626664
From SNPedia
Orientation | plus |
Stabilized | plus |
Geno | Mag | Summary |
---|---|---|
(A;A) | 2 | >1.44x increased risk of developing restless legs syndrome |
(A;G) | 1.5 | 1.44x increased risk of developing restless legs syndrome |
(G;G) | 1 | Normal risk of developing restless legs syndrome |
Reference | GRCh37 37.1/131 |
Chromosome | 9 |
Position | 9261737 |
Gene | PTPRD |
is a | snp |
is | mentioned by |
dbSNP | rs4626664 |
dbSNP (classic) | rs4626664 |
ClinGen | rs4626664 |
ebi | rs4626664 |
HLI | rs4626664 |
Exac | rs4626664 |
Gnomad | rs4626664 |
Varsome | rs4626664 |
LitVar | rs4626664 |
Map | rs4626664 |
PheGenI | rs4626664 |
Biobank | rs4626664 |
1000 genomes | rs4626664 |
hgdp | rs4626664 |
ensembl | rs4626664 |
geneview | rs4626664 |
scholar | rs4626664 |
rs4626664 | |
pharmgkb | rs4626664 |
gwascentral | rs4626664 |
openSNP | rs4626664 |
23andMe | rs4626664 |
SNPshot | rs4626664 |
SNPdbe | rs4626664 |
MSV3d | rs4626664 |
GWAS Ctlg | rs4626664 |
GMAF | 0.2553 |
Max Magnitude | 2 |
? | (A;A) (A;G) (G;G) | 28 |
---|---|---|
|
rs4626664, a SNP in the motor neuron PTPRD gene, has been linked to restless legs syndrome based on a study of several European populations totaling ~2,500 patients. The odds ratio associated with the rs4626664(A) risk allele is 1.44 (CI: 1.31-1.59, adjusted p = 5 x 10e-10). [PMID 18660810]
Note that a nearby SNP, rs1975197, was also shown to independently confer risk for restless legs syndrome in this same study.
GWAS | |
---|---|
SNP | rs4626664 |
PubMedID | [PMID 18660810] |
Condition | Restless legs syndrome |
Gene | PTPRD |
Risk Allele | A |
pValue | 6.00E-010 |
OR | 1.44 |
95% CI | 1.31-1.59 |
[PMID 21264940] Family-based and population-based association studies validate PTPRD as a risk factor for restless legs syndrome